colony-forming unit

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colony-forming unit

a unit of cells in bone marrow capable of generating or increasing the proliferation of new blood cells.

col·o·ny-form·ing u·nit

(CFU) (kol'ŏ-nē-fōrm'ing yū'nit)
1. A stem cell in culture capable of proliferating and differentiating into more mature cells. If the CFU is committed to a specific cell line, it is designated by an additional letter to indicate its commitment; e.g., CFU-E is committed to erythroid maturation; CFU-GM is committed to granulocyte-monocyte maturation.
2. Term used in microbiology to designate a colony formed from a single bacterium or fungus.
References in periodicals archive ?
demonstrated the inhibition of endothelial colony forming cells (ECFCs) by a Src kinase inhibitor, dasatinib, highlighting the use of this technology to measure cellular migration to classify compounds by biological phenotype early in the drug discovery process.
Ploemacher et al, 1999 tested recombinant BMP-9 at a concentration of 3 ng/mL on murine bone marrow cells and found an increased number of colony forming cells in semisolid cultures compared to higher concentrations.
Tests carried out at the New York Blood Center's Placental Blood Program indicated that losses of up to 20% of viable colony forming cells (CFU-C) may occur with only five TWEs in which the temperature of the frozen graft rises to -80 degrees C and losses of up to 50% if the frozen graft rises to -40 degrees C.