familial adenomatous polyposis (redirected from Colon cancer, familial)

familial adenomatous polyposis (FAD),

an inherited disorder characterized by the development of myriad polyps in the colon, beginning in late adolescence or early adulthood. Untreated, the condition nearly always leads to colon cancer. See also adenomatous polyposis coli.

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polyposis [pol″ĭ-po´sis]

the formation of numerous polyps.

familial polyposis (familial adenomatous polyposis (FAP)) a hereditary condition marked by multiple adenomatous polyps with high malignant potential, lining the intestinal mucosa, especially that of the colon. Polyps are first seen around puberty, and by age 35 years 95 per cent of patients have polyps. Without colectomy, colon cancer is inevitable. Extracolonic manifestations may also be present. It occurs as part of several different conditions, including gardner's, peutz-jeghers, canada-cronkhite, and turcot's syndromes.

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familial adenomatous polyposis

Familial polyposis An AD condition affecting ±50,000–US, characterized by progressive development of hundreds of adenomatous colorectal polyps; progression to cancer Molecular pathology APC gene on chromosome 5q21 is mutated in FAP, which may also be mutated in sporadic colorectal tumors Diagnosis Allele-specific expression assay, in vitro synthesized protein assay  Treatment Sulindac