For collision-induced dissociation
(CID), argon was used as the collision gas at a pressure of 1.
3]), in which primary fragment ions, created by collision-induced dissociation
, can be isolated and then further fragmented into secondary fragment ions for quantification.
Recently, one of his major discoveries on the “Formation of the bisulfite anion (HSO3- , m/z 81) upon collision-induced dissociation
of anions derived from organic sulfonic acids” was accepted for publication in the Journal of Mass Spectrometry.
The result is high-efficiency collision-induced dissociation
(C1D) and ultra-fast ion transport, reducing the sensitivity losses and cross talk observed on other systems.
Their topics include human biotransformation, analytical tools and approaches for metabolic identification in drug metabolism, the unanticipated loss of N2 from novel DNA alkylating agent laromustine by collision-induced dissociation
, and strategies for detecting reactive intermediates in drug discovery and development.
According to the company, the result is high-efficiency collision-induced dissociation
(CID) and ultra-fast ion transport, reducing the sensitivity losses and cross talk observed on other systems.
This hybrid LC-MS approach also features various dissociation methods, including Higher-energy Collisional Dissociation in the HCD collision cell (Figure 1) and Collision-Induced Dissociation
in the linear ion trap.
Using peptides commercially available as both acid and amide forms at the C-terminus, fragmentation studies have been conducted using collision-induced dissociation
(CID) and electron transfer dissociation (ETD) mass spectrometry methods with electrospray ionization/quadrupole ion trap (ESI/QIT).
Moreover, the possibility of measuring accurate alkali metal cation affinities with high accuracy by means of different experimental techniques (equilibrium constant determination by high pressure mass spectrometry (HPMS) [1-4] or ion cyclotron resonance (ICR) [5-9], unimolecular dissociation--Cook's kinetic method [4, 10, 11], energy resolved collision-induced dissociation
(CID) [12-14], photodissociation and radiative association kinetics [15, 16]), has stimulated a growing interest in the study of these interactions [17-19].
A chapter covering post-translational modifications describes detection of phosphorylated and glycosylated proteins as well as immunoaffinity chromatography, phosphopeptide mapping, and isotopic labeling and collision-induced dissociation
Between the two TOF separations the samples were passed through a helium-filled collision-induced dissociation
Simple and Compact Options Wanted Computer control 66% Benchtop 57% Electron impact ionization 39% Continuous analysis 29% Dual filaments 29% Atmospheric pressure ionization 26% Interchangeable ion sources 23% Direct desorption probe 20% Error messages 19% Automated sample prep 17% Onboard electronics 16% Preprogrammed analysis 16% Signal preamplifier 14% UHV chamber 14% Energy-selected mass analysis 13% Collision-induced dissociation
13% Digitizer 11% IEEE-488 11% Laser photoionization 10% Source: R&D Magazine Note: Table made from bar graph.