Colace


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docusate sodium

Apo-Docusate Sodium (CA), Colace, Correctol, Correctol Stool Softener (CA), Diocto, Dioctyl (UK), Docusol (UK), Dom-Docusate Sodium (CA), D.O.S. Softgels, Docu-Soft, DOK, D-S-S, DulcoEase (UK), Dulcolax Stool Softener, Enemeez, Genasoft Softgels, Norgalax (UK), Novo Docusate (CA), PHL-Docusate Sodium (CA), PMS-Docusate Sodium, Ratio-Docusate Sodium (CA), Selax (CA), Silace

Pharmacologic class: Emollient

Therapeutic class: Stool softener, surfactant

Pregnancy risk category C

Action

Increases absorption of liquid into stool, resulting in softening of fecal mass. Also promotes electrolyte and water secretion into colon.

Availability

docusate calcium

Capsules: 240 mg

Capsules (soft gels): 240 mg

Rectal solution: 283 mg/5 ml

docusate sodium

Capsules: 50 mg, 100 mg, 250 mg

Capsules (soft gels): 100 mg, 250 mg

Liquid: 150 mg/15 ml

Syrup: 50 mg/15 ml, 60 mg/15 ml, 20 mg/5 ml, 100 mg/30 ml, 150 mg/15 ml

Tablets: 100 mg

Indications and dosages

Stool softener

Adults and children older than age 12: 240 mg (docusate calcium) or 50 to 200 mg (docusate sodium) P.O. daily until bowel movements are normal

Children ages 6 to 12: 40 to 120 mg (docusate sodium) P.O. daily

Children ages 3 to 6: 20 to 60 mg (docusate sodium) P.O. daily

Contraindications

• Hypersensitivity to drug
• Abdominal pain, nausea, or vomiting
• Intestinal obstruction

Precautions

Use cautiously in:
• pregnant or breastfeeding patients.

Administration

• Give tablets and capsules with full glass of water.
• Give liquid solution with milk or fruit juice.
• Be aware that excessive or long-term use may lead to laxative dependence.

Adverse reactions

EENT: throat irritation

GI: nausea, diarrhea, mild cramps

Skin: rash

Other: bitter taste, decreased appetite, laxative dependence

Interactions

Drug-drug.Mineral oil: increased mineral oil absorption, causing toxicity

Warfarin: decreased warfarin effects (with high doses)

Patient monitoring

• If diarrhea occurs, withhold drug and notify prescriber.
• Know that therapeutic efficacy usually becomes apparent 1 to 3 days after first dose.

Patient teaching

• Instruct patient to drink sufficient fluids with each dose and to increase fluid intake during the day.
• Advise patient to prevent constipation by increasing fluids and consuming more dietary fiber (as in fruits and bran).
• Inform patient that excessive or prolonged use may lead to laxative dependence.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

Colace

(kō′lās′)
A trademark for a preparation containing docusate sodium.

Colace

a trademark for a stool softener (docusate sodium sulfosuccinate).
References in periodicals archive ?
ATTENDANCE: 11,211 BARNSLEY Steele; Trippier, Foster, Shackell (c), McEveley; O''Brien, Colace, Arismendi (Butterfield 89), Hammill; O''Connor, Wood (Gray 58).
Colace admits that one of the attractions was that he enjoys playing alongside Urugyuan Diego Arismendi.
Argentinian midfielder Colace, 26, is available on a free transfer after turning down a new deal at Oakwell earlier this summer.
The visitors led 2-1 after Hugo Colace and Daniel Bogdanovic replied to Danny Haynes' second-minute opener, but City bounced back through a Nicky Maynard double, Haynes' second and a penalty from Paul Hartley.
Argentinean midfielder Hugo Colace unleashed a goal-bound volley from the D and somehow Westwood - who must have been unsighted by a crowd of players - dived low to his left to make a brilliant save and further underline just how much the club will miss him if he leaves this transfer window.
Gordon Strachan's shaky start as Middlesbrough boss continued as Barnsley came from behind to triumph 2-1 with goals from Stephen Foster and Hugo Colace.
That advantage had been deservedly given to the hosts seven minutes after the break when Hugo Colace drove the ball home from inside the penalty area.
Burnley fought back with a goal created by Fernando Guerrero and scored by Chris Eagles, but Hugo Colace scored a bullet header with 15 minutes remaining to settle the tie.
BARNSLEY: (4-1-3-2) Muller, Hassell, Foster, Souza (Kozluk, 41) Van Homoet, Colace, Campbell-Ryce, DeSilva, Leon(Rigters, 75), Macken, Cureton.
6,025,050; Ramesh Srinivasan and Angelo Colace, assignors to BBA Nonwovens, Simpsonville, SC.
Wiesel-Levison stresses that the Einstein MS Center tries to "stay away from medications, although sometimes a stool softener such as Colace can be helpful.
One of the most common requests that we've received at Plaxo is for a Mac version of our product," said Drew Colace, lead developer on the project.