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a nonsyphilitic interstitial keratitis characterized by an abrupt onset with vertigo and tinnitus followed by hearing impairment; about 50% of patients have an associated systemic disease, most commonly polyarteritis nodosa.
Synonym(s): Cogan syndrome
Cogan syndromeAn autoimmune condition characterized by interstitial keratitis and bilateral, rapidly progressive audiovestibular dysfunction Clinical Vasculitis of CNS, aorta, heart, pericardium, lungs; ocular complaints–photophobia, blurred vision, lacrimation, pain; Meniere's disease-like Sx–vertigo, ataxia vegetative Sx, with progression to complete absence of vestibular function, manifested by ataxia and oscillopsia, bilateral hearing loss Management High dose steroids, immunosuppression
[David G. Cogan, U.S. ophthalmologist, 1908–1993]
Interstitial keratitis associated with tinnitus, vertigo, and usually deafness.
Cogan,David G., U.S. ophthalmologist, 1908-1993.
Cogan syndrome - a nonsyphilitic interstitial keratitis with vertigo and tinnitus, followed by deafness. Synonym(s): oculovestibulo-auditory syndrome
Cogan-Reese syndrome - syndrome of glaucoma, iris atrophy, decreased corneal endothelium, anterior peripheral synechia, and multiple iris nodules. Synonym(s): iridocorneal endothelial syndrome