Cogan syndrome

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oc·u·lo·ves·tib·u·lo·au·di·to·ry syn·drome

a nonsyphilitic interstitial keratitis characterized by an abrupt onset with vertigo and tinnitus followed by hearing impairment; about 50% of patients have an associated systemic disease, most commonly polyarteritis nodosa.
Synonym(s): Cogan syndrome

Cogan syndrome

An autoimmune condition characterized by interstitial keratitis and bilateral, rapidly progressive audiovestibular dysfunction Clinical Vasculitis of CNS, aorta, heart, pericardium, lungs; ocular complaints–photophobia, blurred vision, lacrimation, pain; Meniere's disease-like Sx–vertigo, ataxia vegetative Sx, with progression to complete absence of vestibular function, manifested by ataxia and oscillopsia, bilateral hearing loss Management High dose steroids, immunosuppression

Cogan syndrome

(kō′găn)
[David G. Cogan, U.S. ophthalmologist, 1908–1993]
Interstitial keratitis associated with tinnitus, vertigo, and usually deafness.

Cogan,

David G., U.S. ophthalmologist, 1908-1993.
Cogan syndrome - a nonsyphilitic interstitial keratitis with vertigo and tinnitus, followed by deafness. Synonym(s): oculovestibulo-auditory syndrome
Cogan-Reese syndrome - syndrome of glaucoma, iris atrophy, decreased corneal endothelium, anterior peripheral synechia, and multiple iris nodules. Synonym(s): iridocorneal endothelial syndrome
References in periodicals archive ?
Differential features of other large cell vasculitides Large cell vasculitis Differential features Kawasaki disease Fever, diffuse mucosal inflammation and dysmorphic skin rashes Cogan's syndrome Interstitial keratitis and acute onset of sensorineural hearing loss and several other neurological manifestations Syphilitic aortitis Skin, mucous membranes manifestations, Negative VDRL Rheumatoid arthritis Joint manifestations Ankylosing spondylitis Sacroilitis Retroperitoneal fibrosis Periaortic and aortic inflammation associated with retroperitoneal and mediastinal fibrosis Behcet's disease Genital and oral aphthous ulcers, uveitis Sarcoidosis Interstitial lung diseases
Large-vessel vasculitides, for instance giant cell arteritis, Takayasu arteritis, Behcet's syndrome, and Cogan's syndrome along with rheumatoid arthritis (RA), ankylosing spondylitis, systemic lupus erythematosus, and relapsing polychondritis may present with noninfectious aortitis.
These disorders include Cogan's syndrome, Meniere's disease, Takayasu's arteritis, rheumatoid arthritis, systemic lupus erythematosus, Behcet's disease and Sjogren's syndrome, among others.
1-3) On the other hand, Parnes et al have been using high-dose dexamethasone--up to 30 and 40 mg/ ml--in humans for the treatment of Cogan's syndrome and sudden autoimmune sensorineural hearing loss, and their results suggest that steroids are not toxic.
Rutka: As mentioned earlier, Parnes et al used high-dose dexamethasone for the treatment of Cogan's syndrome and post-traumatic sensorineural hearing loss, and it did not cause any significant harm to the inner ear.
We compared auditory and vestibular function between a patient with typical Cogan's syndrome and a patient with atypical Cogan's syndrome.
1] This clinical entity is known as typical Cogan's syndrome.
Audiograms of patients with Cogan's syndrome have shown both unilateral and bilateral sensorineural hearing loss with fluctuations.
Electronystagmography (ENG) showed that one of the patients with atypical Cogan's syndrome had direction-changing positional nystagmus, with a failure of optic suppression.
This paper presents an analysis of vestibulo-auditory function and electrocochleographic findings in one case of typical and one case of atypical Cogan's syndrome.
10] This description strongly suggests that this patient had Cogan's syndrome.