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coding sequence |
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Researchers have identified five single-nucleotide polymorphisms that affect PON1 production, three in the promoter region of the PON1 gene (-909, -162, -108) and two in the coding region (L55M, Q192R). Kantoff says that his interest in CAG repeats was sparked when researchers investigating an inherited neuromuscular disorder, Kennedy's syndrome, discovered the repeats in a coding region of the androgen receptor gene. Among the millions of discovered motifs, the team identified approximately 128,000 that also occur in the coding region of the genome and are significantly over-represented in genes involved in specific biological processes such as cell communication, regulation of transcription, transport and others. |
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Coding region
