Cockcroft-Gault formula

Cockcroft-Gault formula

A calculation used to estimate creatinine clearance based on age, weight, serum creatinine, and gender. Estimated creatinine clearance may be used to adjust dosages of renally excreted drugs. This formula is commonly used to adjust dosages for adult patients because their serum creatinine level may be a poor indicator of renal function. Because of decreased muscle mass in elderly patients, the serum creatinine level is a poor indicator of renal function; therefore this formula is used to adjust dosages. For men the formula is (140 – age) (weight in kg)/ 72 × serum creatinine. For women, this result is multiplied by the factor 0.85.
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7,20] The SA 2010 ART guidelines recommended measurement of the serum creatinine concentration before treatment initiation, at 3, 6 and 12 months after initiation and then annually, with calculation of creatinine clearance (CrCl) using the Cockcroft-Gault formula.
A commonly used clinical estimation of renal function is based upon serum creatinine level as a surrogate marker, applying the Cockcroft-Gault formula.
Renal function was assessed by the creatinine clearance (CrCl) estimated using the Cockcroft-Gault formula.
19] It is generally believed that GFR calculated by Cockcroft-Gault formula correlates well with measured GFR when renal function is within the reference interval, but as renal function declines, it overestimates GFR because creatinine is removed not only by glomerular filtration but also by renal tubular secretion.
The substudy analysis calculated estimated glomerular filtration rates (eGFR) for patients enrolled in ARISTOTLE by three difference methods: the Cockcroft-Gault formula, the Chronic Kidney Disease-Epidemiology Collaboration formula, and cystatin C measurement.
Renal function in older hospital patients is more accurately estimated using the cockcroft-gault formula than the modification diet in renal disease formula.
14) Serum creatinine values should be used to estimate GFR by the Modification of Diet in Renal Disease (MDRD) equation or the Cockcroft-Gault formula, although recent results have indicated that the MDRD equation may be more accurate.
The Cockcroft-Gault formula has commonly been used for bedside estimation of renal function based on the patient's age, weight, gender, and serum creatinine (sCr); the formula is provided below in two versions, one using American-favored mg/dL as the unit for sCr, and the other using the international units of micromol/L--note that the later formula employs a different constant value per gender in the numerator of the equation.
Reduced renal function can also be assessed with creatinine-based formulae such as the Cockcroft-Gault formula (5), which calculates creatinine clearance rate in mL/min, or the Modification of Diet in Renal Disease (MDRD) [5] formula, which calculates glomerular filtration rate in mL/min/1.
The Cockcroft-Gault formula is useful for calculating creatinine clearance based on a patient's age, gender, weight, and race.
The GFR in children older than 12 years can be more accurately estimated from the Cockcroft-Gault formula used in adults:
cr]) measured by use of a modified Jaffe method was used to estimate creatinine clearance according to the Cockcroft-Gault formula ([C.