creatinine clearance

(redirected from Cockcroft-Gault equation)

cre·at·i·nine clear·ance

measurement of the clearance of endogenous creatinine, used for evaluating the glomerular filtration rate.

creatinine clearance

Nephrology The ratio of the rate of creatinine excretion in urine to its concentration in serum, a value that reflects the body's ability to excrete creatinine; it is used to diagnose and monitor renal function

cre·at·i·nine clear·ance

(krē-at'i-nin klēr'ăns)
A mathematical calculation of the total amount of creatinine excreted in the urine over a period of time, usually 24 hours to test renal function. The calculation is: creatinine clearance (mL/minute) = urine creatinine concentration (mL/dL) × volume of urine (mL/24 hour) ÷ plasma creatinine concentration (mg/dL) × 1440 minute/24 hour.

clearance

the act of clearing; it is a primary pharmacokinetic parameter which describes irreversible removal of a drug from the body by all processes and is made up of renal clearance and metabolic clearance.

blood-urea clearance
the volume of the blood cleared of urea per minute by renal elimination.
Bromsulphalein clearance
see sulfobromophthalein clearance test.
creatinine clearance
inulin clearance
see inulin clearance.
clearance time
the time required for a drug to be eliminated after administration. Eliminated means to the point where it can no longer be detected. Of most importance in avoiding drug residues in food animals and charges of doping in sports animals.
urea clearance
blood-urea clearance.
References in periodicals archive ?
Previous studies have shown the Cockcroft-Gault equation to be superior for risk prediction (13, 24), and it has by tradition been used for pharmacological dosing and clinical guidance.
In kidney transplantation, the equations most commonly used are the Modification of Diet in Renal Disease (MDRD) Study equation (3, 6), the Cockcroft-Gault equation (2), and the Nankivell equation (4) (see Table 1 in the Data Supplement that accompanies the online version of this Brief Communication at http://www.
The Cockcroft-Gault equation was derived from 236 hospital inpatients in Canada (4% women, ethnicity not stated) with measured creatinine clearance (CrCl) as the reference procedure (mean CrCl 73 mL/ min) (15).
However, neither the MDRD nor the Cockcroft-Gault equation is suitable for estimation of GFR in children, for which other specialized prediction equations must be used, with the equations described by Schwartz et al.
Median GFRs estimated by the Cockcroft-Gault equation varied by as much as 18%, depending on the creatinine method used.
Their prediction equations 6 and 7 decreased unexplained variance from measured GFR by more than one-half when compared with measured creatinine or urea clearance or the Cockcroft-Gault equation, i.
Student t-test, Mann-Whitney U test, and Chi-square test CCS--Canadian Cardiovascular society angina classification, HDL--high-density lipoprotein, LDL--low-density lipoprotein, Ml--myocardial infarction, WMSI--wall motion score index, ** current smokers, *** calculated according to Cockcroft-Gault equation (14) Table 2.
Renal function was determined using the Cockcroft-Gault equation to calculate creatinine clearance (CrCl) and patients were stratified as having normal renal function (CrCl>60 ml/min) or renal impairment (CrCl60 ml/min).
By comparison with the MDRD equation, the Cockcroft-Gault equation tends to overestimate GFR.
Although this equation is a helpful tool, certainly better than use of serum creatinine alone, the Cockcroft-Gault equation yields only an estimate of creatinine clearance and not GFR.
4] Creatinine clearance was calculated using the Cockcroft-Gault equation (for stable creatinine) or the Jeliffe equation[sup.