creatinine clearance

(redirected from Cockcroft-Gault equation)

cre·at·i·nine clear·ance

measurement of the clearance of endogenous creatinine, used for evaluating the glomerular filtration rate.

creatinine clearance

Nephrology The ratio of the rate of creatinine excretion in urine to its concentration in serum, a value that reflects the body's ability to excrete creatinine; it is used to diagnose and monitor renal function

cre·at·i·nine clear·ance

(krē-at'i-nin klēr'ăns)
A mathematical calculation of the total amount of creatinine excreted in the urine over a period of time, usually 24 hours to test renal function. The calculation is: creatinine clearance (mL/minute) = urine creatinine concentration (mL/dL) × volume of urine (mL/24 hour) ÷ plasma creatinine concentration (mg/dL) × 1440 minute/24 hour.

clearance

the act of clearing; it is a primary pharmacokinetic parameter which describes irreversible removal of a drug from the body by all processes and is made up of renal clearance and metabolic clearance.

blood-urea clearance
the volume of the blood cleared of urea per minute by renal elimination.
Bromsulphalein clearance
see sulfobromophthalein clearance test.
creatinine clearance
inulin clearance
see inulin clearance.
clearance time
the time required for a drug to be eliminated after administration. Eliminated means to the point where it can no longer be detected. Of most importance in avoiding drug residues in food animals and charges of doping in sports animals.
urea clearance
blood-urea clearance.
References in periodicals archive ?
The three equations used to estimate GFR include the Cockcroft-Gault equation, which is used by the Food and Drug Administration and most pharmacies; the Modification of Diet in Renal Disease (MDRD) study equation; and the Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI), which is used by most laboratories.
Likewise, the Cockcroft-Gault equation may be less precise as an estimate of GFR in patients with relatively preserved renal function.
Although this equation is a helpful tool, certainly better than use of serum creatinine alone, the Cockcroft-Gault equation yields only an estimate of creatinine clearance and not GFR.
11) Both of these equations, the Cockcroft-Gault equation, (12) and the modified Schwartz equation, (13) which is used for children, incorporate plasma or serum creatinine measurements.
4] Creatinine clearance was calculated using the Cockcroft-Gault equation (for stable creatinine) or the Jeliffe equation[sup.
2] each year according to the Cockcroft-Gault equation.
Creatinine clearance was estimated by the Cockcroft-Gault equation [140-age (years)] x weight (kg)]/[72 x serum creatinine (mg/dl)]; this equation was multiplied by 0.
Renal function was determined using the Cockcroft-Gault equation to calculate creatinine clearance (CrCl) and patients were stratified as having normal renal function (CrCl>60 ml/min) or renal impairment (CrCl60 ml/min).
10-12] Glomerular Filteration Rate (GFR) was calculated by Cockcroft-Gault equation,
Cystatin C is considered equivalent or even superior to other renal markers such as creatinine or creatinine-based estimations of GFR by the Cockcroft-Gault equation (C-G) (6) or the Modification of Diet in Renal Disease equation (MDRD) (1, 3, 4, 7-10).