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A widely used adjective referring to an appearance, morphology or pattern characterised by multiple, similarly-sized rounded densities that project from a single linear surface when the image is 2-D or that rise above a flattened plane when viewed in 3-D, a pattern which has been likened to pre-infernal combustion engine roads paved with ‘cobbled’ stones
Dermatology A term which referred to a common complication of pre-1990 hair replacement surgery—now of historic interest—in which the grafts are bumpy, and do not flatten with time; it is more common in patients with a tendency to form hypertrophic scars. See Hair replacement
Gastroenterology A characteristic radiologic and gross appearance of the intestinal mucosa in Crohn’s disease, due to submucosal involvement; to the endoscopist, cobblestoning refers to the uniform nodules—due to the submucosal edema—while the pathologist refers to severe ulcerative disease with crisscrossing of the ulcers through inflamed but intact mucosa; intestinal ‘cobblestoning’ may also occur in ulcerative colitis—where ulcers alternate with regenerating mucosa, ischaemic colitis, lymphoid hyperplasia of CVID, amyloidosis, mucoviscidosis, pneumatosis cystoides intestinalis, multiple lymphangiomas, and polyposis coli; in the intestine, the mucosal rugosities may correspond to polyps, or be filled with air, lymphoid tissue or amyloid
(1) A term referring to a rare roughened appearance seen by colposcopy of a uterine cervix with Neisseria gonorrhoeae
(2) A finding by hysterosalpingography characterised by rounded filling defects due to intraluminal adhesions
Imaging A term referring to a bumpiness of the greater curvature of the stomach, a finding typical of chronic hypertrophic gastritis
Oral disease A term referring to multiple, closely-set intraoral papilloma-like fibromas that impart a pebbly tactile sensation in Cowden’s premalignant multiple hamartoma syndrome
Ophthalmology Multiple sharply demarcated non-elevated lesions with prominent choroidal vessels, located between the ora serrata and equator, seen in peripheral chorioretinal atrophy, common in ageing, seen in one-fourth of all autopsies, one-third of which are bilateral; aka paving stone degeneration, senile halo
Soft tissue pathology Multiple ‘hobnail’ projections of malignant endothelial cells into the vascular lumina seen in angiosarcoma, a pattern mimicked by Kaposi sarcoma and spindle cell hemangioendothelioma
References in periodicals archive ?
Round and slightly textured, the MUZO Cobblestone has the look and feel of real stone and blends in perfectly with any decor to give homes and work-spaces a Zen-like feel.
We are excited to team up with Walker & Dunlop, Cobblestone and Tricon on the first loan to use our new MHC offering that offers the same certainty of execution as our other loan products," said Peter Giles, regional managing director of Freddie Mac Multifamily.
Other finishes, available in several combinations on select pieces, include Cobblestone, a soft gray paint inspired by French pieces found in Savannah's famed antiques district; Blossom, a chalk white with timeworn rub-through named for the dogwood bloom; and Driftwood, a gray stain, used on tabletops only, which has the casual feel of Low Country Spanish moss.
The annual fundraiser for the festival, the Cobblestone Festival Golf Tournament, will take place on Jun.
COBBLESTONE serves over 22,000 schools nine times a year and offers a lively, historically accurate approach to American history.
Marianne Carus, Editor-in-Chief of Cricket, said, "We are delighted to have the Cobblestone magazines as part of our family.
program today to promote active, healthy lifestyles by building a new Smart Spot playground at Cobblestone Village Apartments.
The event was part of this year's Cobblestone Festival which featured six one-act plays which were well-attended and enjoyed by all.
It is also a significant exporter of steel constructions, cobblestone and plastic and wood joinery.
LOCATION: Cobblestone Courtyard Governor's Residence 2035 North Front Street Harrisburg, PA CONTACT: Kate Philips 717-783-1116
As part of the effort, the area's cracked asphalt and broken cobblestone will be replaced with a new crushed stone surface.