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A widely used adjective referring to an appearance, morphology or pattern characterised by multiple, similarly-sized rounded densities that project from a single linear surface when the image is 2-D or that rise above a flattened plane when viewed in 3-D, a pattern which has been likened to pre-infernal combustion engine roads paved with ‘cobbled’ stones
Dermatology A term which referred to a common complication of pre-1990 hair replacement surgery—now of historic interest—in which the grafts are bumpy, and do not flatten with time; it is more common in patients with a tendency to form hypertrophic scars. See Hair replacement
Gastroenterology A characteristic radiologic and gross appearance of the intestinal mucosa in Crohn’s disease, due to submucosal involvement; to the endoscopist, cobblestoning refers to the uniform nodules—due to the submucosal edema—while the pathologist refers to severe ulcerative disease with crisscrossing of the ulcers through inflamed but intact mucosa; intestinal ‘cobblestoning’ may also occur in ulcerative colitis—where ulcers alternate with regenerating mucosa, ischaemic colitis, lymphoid hyperplasia of CVID, amyloidosis, mucoviscidosis, pneumatosis cystoides intestinalis, multiple lymphangiomas, and polyposis coli; in the intestine, the mucosal rugosities may correspond to polyps, or be filled with air, lymphoid tissue or amyloid
(1) A term referring to a rare roughened appearance seen by colposcopy of a uterine cervix with Neisseria gonorrhoeae
(2) A finding by hysterosalpingography characterised by rounded filling defects due to intraluminal adhesions
Imaging A term referring to a bumpiness of the greater curvature of the stomach, a finding typical of chronic hypertrophic gastritis
Oral disease A term referring to multiple, closely-set intraoral papilloma-like fibromas that impart a pebbly tactile sensation in Cowden’s premalignant multiple hamartoma syndrome
Ophthalmology Multiple sharply demarcated non-elevated lesions with prominent choroidal vessels, located between the ora serrata and equator, seen in peripheral chorioretinal atrophy, common in ageing, seen in one-fourth of all autopsies, one-third of which are bilateral; aka paving stone degeneration, senile halo
Soft tissue pathology Multiple ‘hobnail’ projections of malignant endothelial cells into the vascular lumina seen in angiosarcoma, a pattern mimicked by Kaposi sarcoma and spindle cell hemangioendothelioma
References in periodicals archive ?
Other pieces include The Debonaire Etagere, with cup-and-saucer turned posts and wood framed glass shelves, in Low Tide or in Cobblestone with a Blossom back.
Parking was available on the east and west sides of Grandville Circle south of Cobblestone Drive, and west of the school entrance on the south side of Grandville were it was straight and there was less of a visibility hazard to motorists from parked vehicles, Knap pointed out.
With 22 properties operating and another 40-plus under construction or development, Cobblestone leadership felt the timing was right to partner with LRA to help manage brand and quality assurance during a period of intensive growth.
Tourism authorities in Rome are being plagued by a unique problem, that of tourists, mainly Europeans, and including some British travellers, stealing cobblestones, marble mile markers and pieces of mosaic that are artefacts from ancient Rome, and taking them home with them as souvenirs.
Eight species of tiger beetles, including the cobblestone tiger beetle, have been identified as "Species of Greatest Conservation Need" in New York State's Comprehensive Wildlife Conservation Strategy (New York State Department of Environmental Conservation, 2006) because they are scarce, occur only in small localized areas, with identified threats to their populations (Graves and Brzoska, 1991; Novak, 2006).
Prior to Cobblestone and JBK Capital, Josephson was a senior vice president at Montecito Property Company and, before that, he was a vice president at LNR Property, and a member of the securitization team at UBS.
In the flagship shop, located appropriately off a narrow cobblestone lane, my selection of brown slides were dropped by a clerk from the second floor overhang like manna from heaven.
Cobblestone & Vine, the European gifts and home furnishings store in the Heights, has signed a lease to open a second location in Pleasant Ridge.
The award-winning star of Omagh saw red when asked to leave Dublin's world-famous Cobblestone Bar.
14800 Cobblestone Drive, Silver Spring, MD 209805 (author)