Sodium-glucose co-transporter 2 (SGLT2) inhibitors are a new class of oral antidiabetic medications that act by reducing renal glucose reabsorption in the proximal convoluted tubule thus leading to increased glycosuria and lowering of blood glucose.
Empagliflozin a sodium glucose co-transporter 2 inhibitor in the treatment of type 1 diabetes.
The ratio of this protein to p-actin enabled us to access the regional distribution of the sodium-phosphate co-transporter
Excess production of FGF23 epidermal naevus syndrome Abnormalities of renal Na dependent P co-transporter
: Hereditary hypophosphataemic Inactivating mutation in rickets with hypercalciuria SLC34A3 gene Other defects of renal tubular function: Fanconi syndrome Proximal renal tubular acidosis Distal renal tubular acidosis FGF23, fibroblast growth factor 23; PHEX, phosphate regulating gene with homologies to endopeptidases on the X chromosome; DMP1, dentin matrix protein 1; FRP4, Frizzled-related protein 4; MEPE, matrix extracellular phosphoglycoprotein; SLC34A3, type IIc sodium- phosphate co-transporter
Because dietary adaptation changes the velocity of phosphate transport, dietary-induced changes in reabsorption are likely to remove existing co-transporters or insert new co-transporters into the luminal membrane.
Pi co-transporters on the luminal membrane, thereby decreasing reabsorption.
Phosphorus utilization and renal sodium-phosphorus co-transporter gene expression could be affected by dietary true digestible calcium and phosphorus ratio in post-weaned pigs (Wang et al.
The effect of dietary nutrient density on growth performance, physiological parameters, and small intestinal type IIb sodium phosphate co-transporter expression in broilers.