co-stimulation

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co-stimulation

Immunology The delivery of a 2nd signal from an antigen-presenting cell to a T cell, which rescues an activated T cell from anergy, allowing it to produce the lymphokines necessary for production of additional T cells
References in periodicals archive ?
APX005M is a novel, humanised investigational monoclonal antibody designed to overcome the systemic immune suppression that typically affects cancer patients through activation of CD40, a co-stimulatory receptor on the antigen presenting cells that is essential for activating both innate and adaptive immunity.
Fully owned owned by Alligator, ATOR-1015 binds to two different immune receptors: the checkpoint receptor CTLA-4 and the co-stimulatory receptor OX40.
Verastem announced that a poster highlighting the synergistic effects of duvelisib in combination with immune checkpoint or co-stimulatory antibodies in preclinical models of B cell lymphoma was presented at ASCO-SITC Clinical Immuno-Oncology Symposium being held January 25-27.
B cells require a co-stimulatory signal together with antigen recognition for B cell activation.
In response to sensing the danger signals by PRRs such as toll-like receptors, APCs produce co-stimulatory molecules and polarizing cytokines that promote adaptive immunity into the best responses against the danger signals.
The balance of co-stimulatory and co-inhibitory molecules, which are expressed on T-cells control the immunological response, is crucial in the adaptive immunosuppression induced by sepsis.
Engagement of T cells requires two signals: antigen recognition through the T cell receptor (TCR) and major histocompatibility complex (MHC); and co-stimulatory or co-inhibitory signals.
MHC associated antigen presentation and interaction of co-stimulatory molecules particularly T-cell surface specific glycoprotein CD28 with T-cell activation antigens CD80 and CD86 that are expressed on antigen presenting cells15.
Varlilumab is Celldex's fully human monoclonal agonist antibody that binds and activates CD27, a critical co-stimulatory molecule in the immune activation cascade.
It functions as a negative co-stimulatory molecule for the T cell.
Objective: The co-stimulatory molecule B7-H3 plays an important role in prognosis of several malignancies.
The acquisition gives Bristol-Myers Squibb full rights to Cormorant's HuMax-IL8 antibody programme and the lead candidate HuMax-IL8, a Phase 1/2 monoclonal antibody targeted against interleukin-8 that represents a potentially complementary immuno-oncology mechanism of action to T-cell directed antibodies and co-stimulatory molecules.