co-stimulation

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co-stimulation

Immunology The delivery of a 2nd signal from an antigen-presenting cell to a T cell, which rescues an activated T cell from anergy, allowing it to produce the lymphokines necessary for production of additional T cells
References in periodicals archive ?
APX005M targets CD40, a co-stimulatory receptor that is essential for activating both innate and adaptive immune systems.
With the addition of a potentially best-in-class IDO1 inhibitor and the broad IDO/TDO programs, Bristol-Myers Squibb will accelerate its ability to explore numerous immunotherapeutic approaches across tumor types, including combinations with our biologic checkpoint and co-stimulatory agents that target different and complementary pathways.
GBR 830 is an antagonistic monoclonal antibody with first in class potential for the treatment of autoimmune diseases targeting OX40, a co-stimulatory receptor on T cells
The microarray analysis was performed to evaluate the innate immunity and demonstrated that AG significantly induced the expression of cytokines, chemokines, and co-stimulatory receptors, such as IL-1[alpha], CXCL2, and CD69.
Co-stimulatory molecules and cytokines deliver the second and third signals [3,4].
Furthermore, 1,2510H)2D3 inhibits dendritic cell (DC) differentiation and maturation, leading to down-regulated expression of major histocompatibility complex class II molecules (MHC-Il), co-stimulatory molecules and IL-12; enhances IL-10 production and promotes DC apoptosis.
The DC maturation results in increased surface expression of MHCs and co-stimulatory molecules CD40 and CD80/86 (3), and production of cytokines (IL-12, IFN-[alpha]) (4), thereby allowing efficient T cell activation.
These findings, together with those demonstrated in our earlier studies, are unique among the molecules targeting the B7 family of co-stimulatory molecules that have been published to date.
These antigens, either alone or in combination with other co-stimulatory molecules, are then recognized as foreign by the person's immune system, which will then hopefully attack the tumor, instead of ignoring it as it normally does.
9] The name "Tricom" shorthand for a combination of three powerful co-stimulatory molecules--B7-1, ICAM, and LFA-3 enhance T-cell response.
It down-regulates the expression of The cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages.
7) Moreover, they are able to alter the local cytokine milieu, T-cell priming and co-stimulatory signalling thus skewing the immune balance towards Th2-driven responses.