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Immunology The delivery of a 2nd signal from an antigen-presenting cell to a T cell, which rescues an activated T cell from anergy, allowing it to produce the lymphokines necessary for production of additional T cells
With the addition of a potentially best-in-class IDO1 inhibitor and the broad IDO/TDO programs, Bristol-Myers Squibb will accelerate its ability to explore numerous immunotherapeutic approaches across tumor types, including combinations with our biologic checkpoint and co-stimulatory agents that target different and complementary pathways.
The microarray analysis was performed to evaluate the innate immunity and demonstrated that AG significantly induced the expression of cytokines, chemokines, and co-stimulatory receptors, such as IL-1[alpha], CXCL2, and CD69.
Furthermore, 1,2510H)2D3 inhibits dendritic cell (DC) differentiation and maturation, leading to down-regulated expression of major histocompatibility complex class II molecules (MHC-Il), co-stimulatory molecules and IL-12; enhances IL-10 production and promotes DC apoptosis.
The DC maturation results in increased surface expression of MHCs and co-stimulatory molecules CD40 and CD80/86 (3), and production of cytokines (IL-12, IFN-[alpha]) (4), thereby allowing efficient T cell activation.
These antigens, either alone or in combination with other co-stimulatory molecules, are then recognized as foreign by the person's immune system, which will then hopefully attack the tumor, instead of ignoring it as it normally does.