coreceptor

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co·re·cep·tor

(kō'rē-sep'tōr),
A cell surface receptor, which, when bound to its respective ligand, modulates antigen receptor binding or affects cellular activation after antigen-receptor interactions.

co·re·cep·tor

(kō'rĕ-sep'tŏr)
A cell surface protein that increases the sensitivity of the antigen receptor to antigen by binding to other ligands.

coreceptor

(ko?re-sep'tor) [ com- + receptor]
A structure on a cell membrane that enhances the action of the cell receptor.

CCR5 coreceptor

A cell surface receptor found on macrophages that facilitates entry of HIV-1 into these cells. Chemokines released by T cells attempt to compete with HIV by blocking the receptor to prevent infection.

CXCR4 coreceptor

A cell surface receptor found on T cells that facilitates entry of HIV-1into these cells.
Synonym: fusin
References in periodicals archive ?
The new study builds on previous discoveries by the Farzan laboratory, which show that a co-receptor called CCR5 contains unusual modifications in its critical HIV-binding region, and that proteins based on this region can be used to prevent infection.
Although the HIV virus was initially discovered to infect cells via a receptor called CD4, researchers found in 1996 that HIV infection requires a co-receptor, usually CCR5.
What's more, blocking the receptor with the CCR5 antagonists Maraviroc and Vicriviroc, two drugs that slow down the spread of the HIV virus by targeting the CCR5 co-receptor of the chemokine CCL5, also prevents migration and spread of breast cancer cells, the researchers found.
Further, the expression of HIV-1 co-receptor molecules: CXCR4 and CCR5, and co-stimulatory molecules: CD40 and CD86 were analysed on the two DC subsets.
Trofile is a patient selection co-receptor tropism assay that determines whether a patient is infected with a strain of HIV that uses the CCR5 co-receptor, the CXCR4 co-receptor, or a combination of CCR5 and CXCR4 to enter cells.
Specifically, on the cell surface, PGRP-LE exerts such effects as a co-receptor of PGRP-LC, one of the PGRP family members.
Pfizer and Monogram to Make HIV Co-Receptor Tropism Assay Available Globally
the Myriad Genetics BRCA1 patent, the University of Miami Canavan disease patent, the CCR5 HIV co-receptor gene patent).
This article examined the central role played by co-receptor expression and usage in the transmission and pathogenic effects of HIV-1 infection of humans.
In addition, newer agents with novel mechanisms of action, such as HIV entry inhibitors (which inhibit the three steps of HIV entry: CD4 attachment, chemokine co-receptor binding and membrane fusion) and HIV integrase inhibitors, are also under investigation.