Cmax


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maximum concentration

The peak concentration that a drug achieves in a specified compartment after the drug has been administrated and before administration of a second dose. Cmax is the opposite of Cmin—which is the minimum (or trough) concentration that a drug achieves after dosing.

Cmax

Pharmacology The peak serum concentration of a therapeutic drug. See Pharmaco-kinetics, Tmax. Cf Trough.

Cmax

Maximum concentration of a drug achieved after dosing.

Cmax

in pharmcokinetics, the maximum plasma concentration of the drug.
References in periodicals archive ?
The Cmax for pimobendan tablet suspension was > 6 times higher than the Cmax for pimobendan powder suspension (8.
No prices have yet been suggested for CMax but it will hit UK roads in September with a choice of 1.
Fluoroquinolones also differ in pharmacokinetic parameters, such as Cmax and AUC (39).
When not in their cells, each of the 480 CMAX inmates may be allowed to shower three times a week, to visit a small exterior exercise area for "walks" or calisthenics, or to make brief trips to an in-pod library cell.
Pharmacokinetic: The following parameters were used in the data analysis for plasma sildenafil and N-desmethylsildenafil concentrations: AUC0-t, The area under the plasma concentration versus time curve, from time 0 to the last measurable concentration; AUC0-inf, Calculated as the sum of the AUC0-t plus the ratio of the last measurable plasma concentration to the elimination rate constant; AUC0-t/AUC0-inf, The ration of the AUC0-t to AUC0-inf; Cmax, The maximum measured plasma concentration observed; Tmax, defined as the time point of Cmax; Kel, The apparent first-order terminal elimination rate constant; T1/2, The apparent first-order terminal elimination half-life; Ratio Metabolite/Parent, The ratio of the metabolite/parent assessed at each concentration, Cmax, AUC0-t, AUC0-inf.
The ratios of Cmax and overall exposure (AUC0-inf) for Egalet-001 in the presence of food compared to Egalet-001 in the fasted state were both in the range of bioequivalence; and,
When co-administered with pitavastatin, the Cmax and AUC0-Ia of darunavir increased by 6% and 3% respectively, and the Cmax and AUC0-Ia of ritonavir increased by 2% and 8%, respectively.
The registration number of Peter's Ford CMax car is almost identical to the car photographed in the Sheffield bus lane - apart from two digits.
Originally launched in the Ford Focus and CMAX, the transmission is now also available on the Kuga, Mondeo, SMAX and Galaxy.
The 5008 Compact MPV will be a rival for the likes of Citroen's C4 Grand Picasso and the recently announced Ford Grand CMax.
The PARI Tobramycin 100 Cmax level for the overall, adult and non-adult population was 1.
The study will take place in Adelaide, Australia under the management of CMAX, a Division of the Institute of Drug Technology Australia Limited.