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clusterin |
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clusterin [klus′terin] a multifunctional glycoprotein with roles in the metabolism and transport of lipids and membrane fragments, secretion of hormones, reproductive biology, inhibition of assembly of the membrane attack complex of complement activation, programmed cell death, and modulation of intercell interactions. Its expression is enhanced in tissue injury and remodeling, and in degenerative diseases such as Alzheimer's disease. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| Increased clusterin expression protects prostate cancer cells from the cytotoxic effects of hormone ablation and chemotherapy and elevated levels of clusterin are associated with hormone resistance and metastasis. The Case research team discovered that the human body increases production of the protein clusterin as a signal of cell distress and provides a reliable gauge of the general health of a cell. Responsiveness of endometrial genes connexin26, connexin43, C3 and clusterin to primary estrogen, selective estrogen receptor modulators, phyto- and xenoestrogens. |
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