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Lead investigator Professor Robert Kerwin said that wider use of Clozaril could save between 50 and 100 lives a year in the UK.
We already knew that Clozaril could help people with schizophrenia,'' said Prof Kerwin, who is professor of clinical neuropharmacology at the Institute of Psychiatry, King's College, London.
said in an interview that the reduction in the frequency of monitoring after 1 year was based on considerations of data from the Clozaril National Registry and experience in the United Kingdom and Australia.
Novartis, which manufactures Clozaril, the trade formulation, is planning to send out a "Dear Health Care Provider" letter explaining the changes in the monitoring schedule as well as several other unrelated changes on the label.
Postmarketing data suggest that Clozaril is "associated with an increased risk of fatal myocarditis," especially during the first month of therapy.
Data from clozapine treatment registries in the United Kingdom and Texas also showed a reduced suicide rate associated with Clozaril.
This suggests that Clozaril is a very effective medication for controlling aggression and the symptoms of psychosis," Dr.
In this study, FazaClo was administered without any liquids and Clozaril was administered with liquids.
drug levels in the blood of patients are equal) between Clozaril and Clozapine," stated Sanford Bolton, Ph.
They knew they were being switched off - and back onto - their long standing medication, Clozaril.
Weekly white blood cell counts and weekly drug dispensing mandatory because of the risk of agranulocytosis, which can be reversed if detected early Postmarkering data suggest that Clozaril is "associated with an increased risk of fatal myocarditis," especially during the first month.