Cloverleaf Structure

The normal planar representation of tRNA, which folds back upon itself to allow maximum stability by forming multiple hydrogen intrachain bonds at the ‘arms’ of the cloverleaf; the segments of RNA that are not hydrogen-bonded are termed ‘loops’
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The molecular mechanisms related to the switch from the acute to the persistent CV-B infection in human cardiac tissue are still unknown, but they could be related to terminal deletions on the 5' NCR cloverleaf structure, resulting in low replication levels.
These deletions induce a loss of a part of the 5' untranslated region cloverleaf structure, but the viral RNA polymerase (3CD) binding site remains intact (11).