Clotting factors

Clotting factors

Substances in the blood that act in sequence to stop bleeding by forming a clot.

Mentioned in: Partial Thromboplastin Time

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clotting factors,

n.pl the chemical and cellular constituents of the blood responsible for the conversion of fibrinogen into a mesh of insoluble fibrin causing the blood to coagulate or clot.

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clotting

the formation of a jellylike substance over the ends or within the walls of a blood vessel, with resultant stoppage of the blood flow. Clotting is one of the natural defense mechanisms of the body when injury occurs. A clot will usually form within 5 minutes after a blood vessel wall has been damaged. The clotting mechanism is triggered by the platelets, which disintegrate as they pass over rough places in the injured surface. As they disintegrate they release serotonin and thromboplastin. Serotonin causes constriction of the blood vessels and reduction of local blood pressure. Thromboplastin unites with calcium ions and other substances which promote the formation of fibrin. When examined under a microscope, a clot consists of a mesh of fine threads of fibrin in which are embedded erythrocytes and leukocytes, small amounts of fluid (serum), and platelets.

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clotting defects

see coagulopathy.

clotting factors

a series of plasma proteins which are related through a complex cascade of enzyme-catalyzed reactions involving the sequential cleavage of large protein molecules to produce peptides, each of which converts an inactive zymogen precursor (factor II) into an active enzyme (Iia) leading to the formation of a fibrin clot. They are designated by Roman numerals, and an additional 'a' to indicate the activated state. They are: factor I (fibrinogen), factor II (prothrombin), factor III (tissue thromboplastin), factor IV (calcium), factor V (proaccelerin), factor VI (no longer considered active in hemostasis), factor VII (proconvertin), factor VIII (antihemophilic factor), factor IX (plasma thromboplastin component; Christmas factor), factor X (stuart factor), factor XI (plasma thromboplastin antecedent), factor XII (hageman factor), factor XIII (fibrin stabilizing factor).

clotting time

the time required for blood to clot in a glass tube; a measure of the intrinsic system of coagulation. In the Lee-White method, blood in test tubes is maintained at a constant temperature and examined regularly until clotting occurs; the test can be also be performed in capillary tubes. Called also coagulation time. Less sensitive and now less often used than the activated coagulation time.

tissue clotting factor

clotting factor III; tissue thromboplastin.