clotrimazole /clo·trim·a·zole/ (klo-trim´ah-zōl) an imidazole derivative used as a broad-spectrum antifungal agent.
clotrimazole
clotrimazole [klo-trim´ah-zōl]
clotrimazole (klōtrim´
zōl´),
clotrimazole
clo·trim·a·zole (kl -tr m  -zl )n. A broad-spectrum antifungal drug used topically to treat a variety of superficial fungal infections, including candidiasis and tinea. |
clotrimazole
[klōtrim′əzōl]
a broad-spectrum antifungal agent of the imidazole group used in topical applications to treat fungal and yeast infections, including tinea pedis, tinea cruris, tinea corporis, tinea versicolor, oral candidiasis, and vaginal candidiasis.
indications It is prescribed in the treatment of superficial fungal infections and candidal vulvovaginitis. Oral troches are used for prophylaxis against fungal infections in neutropenic patients.
contraindications Known hypersensitivity to this drug prohibits its use. It is not prescribed for ophthalmic use; contact with eyes should be avoided.
adverse effects The most serious adverse reactions are severe hypersensitivity reactions of the skin. The use of oral troches often causes liver enzyme abnormalities.
clotrimazole [klo-trim´ah-zōl]
a synthetic broad-spectrum antifungal agent applied topically to the skin in the treatment of candidiasis and various forms of tinea, and administered intravaginally in the treatment of vulvovaginal candidiasis and orally in the prevention and treatment of candidiasis of the mouth and throat.
clotrimazole (klōtrim´
zōl´),n brand names: Lotrimin, Canesten, Gyne-Lotrimin, Mycelex-7, Mycelex Troches;
drug class: inidazole antiinfective;
action: interferes with fungal DNA replication;
uses: tinea pedis, tinea cruris, tinea corporis, tinea vesicolor, and
C. albicans infection of the oral cavity, pharynx, vulva, and vagina.
drug class: inidazole antiinfective;
action: interferes with fungal DNA replication;
uses: tinea pedis, tinea cruris, tinea corporis, tinea vesicolor, and
C. albicans infection of the oral cavity, pharynx, vulva, and vagina.
clotrimazole
a synthetic imidazole derivative with antifungal activity, similar to ketoconazole; applied topically in the treatment of diseases caused by dermatophytes and yeasts.
antifungal agent
Any substance which destroys or prevents the growth of fungi. It is one of the antibiotic groups. There are several classes of antifungal drugs: Polyenes, which cause an increase in fungal cell wall permeability leading to its death. Examples: amphotericin B, natamycin, nystatin. Azoles, which act either by inhibiting the synthesis of ergosterol, a component of fungal cell wall or by causing direct wall damage. Examples: clotrimazole, econazole, fluconazole, itraconazole, ketoconazole, miconazole. Pyrimidines, which interfere with the normal function of fungal cells. Example: flucytosine. Syn antimycotic agent.
clotrimazole
Infectious disease An antifungal imidazole used topically for candidiasis Adverse effects Nausea, dizziness, diarrhea, changed LFTs
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