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0 ng/ml of clonidine hydrochloride and each sample was processed as described.
The LLOQ and LOD for clonidine hydrochloride was proved to be 0.
The extraction recovery determined for clonidine hydrochloride was shown to be consistent, precise and reproducible.
As indicated, the developed method shows an acceptable intermediate precision for clonidine hydrochloride assay.
Table 6 summarizes the freeze and thaw stability, short term stability, long-term stability and post-preparative stability data of clonidine hydrochloride.
In general, the pharmacokinetic parameters for both formulations were similar to the pharmacokinetic parameters of clonidine hydrochloride in previous published data.
A sensitive, selective, accurate and precise HPLC method with selected ion monitoring by triple quadrupole mass spectrometer with ESI interface was developed and validated for determination of clonidine hydrochloride in human plasma.
APP said that it will launch Clonidine Hydrochloride Injection immediately and market the analgesic in 1000 mcg/10 ml and 5000 mcg/10 ml single dose vials.
According to the company, this approval of Clonidine Hydrochloride further strengthens its analgesic portfolio of products and helps solidify its continued leadership as a leading generic injectable company.
Clonidine Hydrochloride is a centrally-acting analgesic, which is indicated in combination with opiates for the treatment of severe pain in cancer patients that is not adequately relieved by opioid analgesics alone.
7 million prescriptions were dispensed for clonidine hydrochloride tablets and approximately 1.
Clonidine hydrochloride is an alpha-2 agonist approved for the treatment of hypertension.