clonal selection


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Related to clonal selection: clonal expansion

clonal selection

1. The process by which T lymphocytes with receptors that react to autoantigens are destroyed in the thymus.
2. The increase of particular B or T lymphocyte clones after recognition of a specific antigen to which the body has been exposed.
See: negative selection; clone
See also: selection

clonal selection

The production by an antigen of an expanding CLONE of lymphocytes from a single cell bearing a receptor complementary to the antigen.
References in periodicals archive ?
Next, these coefficients were energized as indicated in formula (4), normalized, and input into the clonal selection classifier to determine the fault class.
The fundamental idea is detecting the irrelevant traces and helping learners by identifying wrong scenarios using AIS techniques, especially negative and clonal selection.
Through the proportional clonal, mutation and clonal selection, the proposed algorithm performs a greedy search which reproduces antibodies and selects their improved offspring after the affinity maturation process.
The clonal selection algorithm is then applied to the new population.
The basis for the clonal selection algorithm is the natural B-cell mechanism (Sabine, 2007).
Clonal Selection is based on the way in which both B-cells and T-cells adapt in order to match and kill the foreign cells [11].
Cancer is a process of clonal selection, and analytical methods from evolutionary biology should be able to explain why cancer tissues are heterogeneous and develop resistance to current therapies.
Although a lot of efforts are made on the clonal selection, there are often few little to no optimizations done on the media and associated feeds used for the upstream process.
Clonal selection drives genetic divergence of metastatic medulloblastoma.
antigens and detectors, which are represented respectively based on attribute-gene and constraint-based GEP, 2) avidity/affinity functions considering attribute-priority, and 3) an avidity-model based clonal selection (AMCS) algorithm inspired by the clonal selection and avidity model of BIS.
To implement the clonal selection algorithm and develop the upgrade plan, operations and resource limitations are introduced as antibodies.
This two-volume proceedings set gathers together papers addressing a very wide range of theories, methodologies, and applications, including, for example, studies of the design of a microcomputer control system for a step motor, modeling fleet planning strategy, a virtual simulation system for a tunnel boring machine, using semantic web for information retrieval based on clonal selection strategy, and an image retrieval algorithm based on color segment and shape moment invariants, among many other topics.