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clomiphene citrate (clomifene (UK))

Clomid, Serophene

Pharmacologic class: Chlorotrianisene derivative

Therapeutic class: Fertility drug, ovulation stimulant

Pregnancy risk category X


Binds with estrogen receptors in cytoplasm, increasing secretion of folliclestimulating hormone, luteinizing hormone, and gonadotropin in hypothalamus and pituitary gland. These actions induce ovulation.


Tablets: 50 mg

Indications and dosages

Ovarian failure

Adults: 50 mg/day P.O. for 5 days starting any time in patients with no recent uterine bleeding; or 50 mg/day P.O. starting on fifth day of menstrual cycle. If ovulation doesn't occur, increase to 100 mg/day P.O. for 5 days. Start next course of therapy as early as 30 days after previous course. If patient doesn't respond after three courses, no further doses are recommended.

Off-label uses

• Male sterility (controversial)


• Hepatic disease

• Organic intracranial lesions

• Uncontrolled thyroid or adrenal dysfunction

• Ovarian cyst

• Abnormal uterine bleeding or bleeding of undetermined origin

• Pregnancy




• Obtain pregnancy test before therapy begins.

• Be aware that patient should undergo pelvic and eye examinations before starting therapy.

Adverse reactions

CNS: nervousness, insomnia, dizziness, light-headedness

CV: vasomotor flushing

EENT: visual disturbances

GI: nausea; vomiting; abdominal discomfort, distention, and bloating

GU: breast tenderness, ovarian enlargement, multiple pregnancies, birth defects in resulting pregnancies, ovarian hyperstimulation syndrome, uterine bleeding


None significant

Patient monitoring

• Monitor patient for bleeding and other adverse reactions.

Patient teaching

Instruct patient to immediately report signs and symptoms of ovarian hyperstimulation syndrome, including nausea, vomiting, diarrhea, abdominal or pelvic pain, and swelling in hands or legs.

• Tell patient to report bleeding.

• Advise patient not to take drug if she is or may become pregnant.

• Inform patient that drug increases risk of multiple births, which heightens maternal risk.

• As appropriate, review all other significant and life-threatening adverse reactions.


A trademark for the drug clomiphene.


a trademark for a nonsteroidal fertility drug (clomiPHENE citrate).


A brand name for CLOMIPHENE (clomifene).
References in periodicals archive ?
She knew that the success rates for IVF were higher than Clomid and by undergoing treatment she was more likely to have a baby.
The GP-patient told me that in her private practice, because of anecdotal research, she advises women not to take gonadotropin injections or Clomid, even for the recommended period of less than six months, but that she had been taking Clomid for eight months and was terrified of what she was doing to her body.
Shoe shop assistant manager Karen has a problem with her ovaries and is starting a course of the drug Clomid to encourage her to produce more eggs.
Por ejemplo, hasta un 10 por ciento de las mujeres que toman el farmaco Clomid (citrato de clomifeno) tienen gemelos y 1 de cada 400 tiene trillizos.
Christine Brody put Benitez on a hormonal drug called Clomid, to treat her polycystic ovarian syndrome, and also told her that she was willing to oversee her treatment but not to perform inseminations because, as a Christian, she disapproved of lesbians having children.
This is me, a ball of contradictions--in the day taking clomid to get pregnant and at night attempting to skateboard in a supermarket parking lot.
BURBANK - The oldest daughter of Bonny Lee Bakley testified Tuesday in the Robert Blake wrongful death trial that her mother took the fertility drug Clomid instead of birth control pills she had told the actor she was taking.
Is it malpractice to start such a woman on Clomid instead of teaching her to slightly tweak her diet and exercise regimen?
Instead, Dianne found herself charting her temperature on a lunar axis, gobbling Clomid, bending eventually over the night table for shots of Pergonal-made in Helvetia from the urine of post-menopausal Heidis.