DST was conducted for first-line drugs during the first month of treatment, for second-line drugs during the second month of treatment, for linezolid during the fourth month, and for clofazimine
during the seventh month.
(Lamprene, B663) in the treatment of lepromatous leprosy in the United Kingdom.
The World Health Organization recommends multidrug therapy consisting of Dapsone, rifampin, and clofazimine
Most patients of Type 2 lepra reaction respond to prednisolone, clofazimine
and thalidomide therapy, but we had received a few patients of Type 2 lepra reaction in whom prednisolone and thalidomide were unable to induce remission.
He was treated for 44 months with a daily regimen of dapsone (100 mg), clofazimine
(100 mg), and rifampin (600 mg).
1) For multibacillary patients like our patient, the WHO recommends MDT with supervised doses of 600 mg rifampin and 300 mg clofazimine
once monthly, and unsupervised clofazimine
50mg/day and dapsone 100mg/day for 12 months.
Alternative therapies include dapsone, sulfapyridine, methotrexate, clofazimine
, minocycline, colchicine, intravenous immunoglobulins and anti-TNF-a agents.
delamanid for the treatment of children and adolescents with multidrug-resistant tuberculosis (MDR-TB) and clofazimine
for children and adults with MDR-TB;
Other new options include pretomanid, and older repurposed drugs such as clofazimine
Contract awarded for Requirement: 17-218589 clofazimine
100mg, capsula, voft10414
4 patients developed sensitivity to dapsone while on treatment and the offending drug was substituted with ofloxacin in 3 multibacillary cases and with clofazimine
in the paucibacillary patient.
Five patients who had previously received MDT therapy and presented with features of acute neuritis, were treated with oral prednisolone 1 mg/kg tapered over 4-6 months and clofazimine