Because clock-1 affects longevity in invertebrates and mice, and because we're talking about three age-dependent neurodegenerative diseases, we hypothesize that clioquinol affects them by slowing down the rate of aging," Hekimi added.
Hekimi said that the exact mechanism of how clioquinol inhibits CLK-1 is till under investigation.
Vaccines to prevent AD have fallen short because they target amyloid beta indiscriminately, whereas clioquinol
goes after the toxic, aggregated form of the protein, Dr.
One-third of young mice treated with clioquinol
didn't develop detectable amyloid deposits; the others had far fewer than untreated mice did.
, which was developed 100 years ago, is able to absorb the zinc and copper atoms that concentrate in the brains of Alzheimer's sufferers such as former US President Ronald Reagan before dementia sets in.
Use of a Cu-Zn chelator, such as clioquinol
, inhibits A[beta] accumulation in AD transgenic mice [174, 175], which highlights the importance of studying copper and zinc binding to A[beta].
Antibiotic and chelating agent clioquinol
has decreased AB deposition in trials.
For instance, clioquinol
is a zinc/copper ionophore that facilitates the clearance of A[beta] aggregates in the cortex of animal models of AD.
Lim, "Effects of clioquinol
on metal-triggered amyloid-[beta] aggregation revisited," Inorganic Chemistry, vol.
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