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clinical trial |
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trial /tri·al/ (tri´al) (trīl) a test or experiment. clinical trial an experiment performed on human beings in order to evaluate the comparative efficacy of two or more therapies.
Clinical trial All new drugs undergo clinical trials before approval. Clinical trials are carefully conducted tests in which effectiveness and side effects are studied, with the placebo effect eliminated. Mentioned in: Gene Therapy, Multiple Sclerosis
clinical trial, n a trial based upon the scientific method in which a control group and a test group are compared over time in order to study a single, differing factor.
trial, randomized controlled (RCT) An experimental design used for testing the effectiveness of a new medication or a new therapeutic procedure. Individuals are assigned randomly to a treatment group (experimental therapy) and a control group (placebo or standard therapy) and the outcomes are compared. The trial is strengthened by 'blinding' or masking (single-blind, double-blind or triple-blind study) and cross-over design. RCT is the most accepted scientific method of determining the benefit of a drug or a therapeutic procedure. It represents the best evidence available, which is integrated into the final decision about the management of a condition by healthcare practitioners in what is called evidence-based healthcare. Syn. randomized clinical trial. See sampling; significance; study.
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Over the past few years there has been a proliferation of clinical studies. Despite the optimism generated among scientists by successfulnew treatments, Friedman says the inadequate number of cancer patients in clinical studies is limiting progress--and that this lack of subjects is a problem in cancer research worldwide. With five clinical studies in progress, the goal is to build a deep pipeline of preclinical and clinical programs, conducted by partners, that may further validate the potentially pivotal role Inovio's technology may play in delivering and enhancing the potency of promising DNA vaccines as well as identify and validate promising DNA vaccines themselves. |
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