clearance

clearance /clear·ance/ (kler´ans)

1. the act of clearing.

2. a quantitative measure of the rate at which a substance is removed from the blood, as by the kidneys, the liver, or hemodialysis; the volume of plasma cleared per unit time. Symbol C.

3. the space between opposed structures.

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blood-urea clearance  urea c.

creatinine clearance  the volume of plasma cleared of creatinine after parenteral administration of a specified amount of the substance.

inulin clearance  an expression of the renal efficiency in eliminating inulin from the blood.

mucociliary clearance  the clearance of mucus and other materials from the airways by the cilia of the epithelial cells.

urea clearance  the volume of the blood cleared of urea per minute by either renal clearance or hemodialysis.

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clear·ance (klîrns)

n.

The removal of a substance from the blood, expressed as the volume of blood or plasma cleared of the substance per unit time.

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clearance,

n 1. a condition in which moving bodies may pass without hindrance.
2. removal from the blood by the kidneys (e.g., urea or insulin) or by the liver (e.g., certain dyes).

clearance, interocclusal

n the difference in the height of the face when the mandible is at rest and when the teeth are in occlusion. This is determined by measuring the amount of space between the maxillary and mandibular teeth when the mandible is in the position of physiologic rest. The difference between the rest vertical dimension and the occlusal vertical dimension of the face, as measured in the incisal area. See also distance, interocclusal.

clearance, occlusal

n a condition in which the mandibular teeth may pass the maxillary teeth horizontally without contact or interference.

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clearance

the act of clearing; it is a primary pharmacokinetic parameter which describes irreversible removal of a drug from the body by all processes and is made up of renal clearance and metabolic clearance.

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blood-urea clearance

the volume of the blood cleared of urea per minute by renal elimination.

Bromsulphalein clearance

see sulfobromophthalein clearance test.

creatinine clearance

see creatinine.

inulin clearance

see inulin clearance.

clearance time

the time required for a drug to be eliminated after administration. Eliminated means to the point where it can no longer be detected. Of most importance in avoiding drug residues in food animals and charges of doping in sports animals.

urea clearance

blood-urea clearance.