Clear Cell Tumour

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A benign or malignant neoplasm composed of clear cells that may be of any embryologic (endo-, ecto-, meso-) or neuroectodermal origin; the cytoplasmic clearing may be real—lipid, mucopolysaccharide and mucosubstance—or artifactual, due to post-fixation shrinkage of cytoplasmic content away from an intact and more rigid cell membrane
Examples, clear cell tumours Balloon cell melanoma, signet ring cell carcinomas, renal cell, adrenal, ovary, parathyroid and thyroid carcinomas, clear cell tumours of tendons & aponeuroses, germ cell tumours—e.g., seminomas, dysgerminoma—histiocytosis X, lymphoma—B- and T- clear cell lymphomas—myeloma, clear cell type, myxoid lesions—benign and malignant—paraganglioma, and xanthoma. See Clear cell carcinoma
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The resection of the tumor showed a clear cell tumor embedded in a rich capillary network, similar to previously described cases in this review.
The index case was such an example, where a small biopsy of an epithelioid clear cell tumor, clinically thought to be a metastatic carcinoma, was initially presumed to be an RCC based on the CD10 positivity.
The clear cell tumor component grew in solid, papillary, tubular, and acinar patterns with focal melanin pigmentation.
Benign lung tumors in the differential diagnosis include clear cell tumor, pulmonary hamartoma, and hemangioma.
In 1972, Donath et al (7) described 8 cases of a previously unrecognized clear cell tumor of salivary gland origin, which they termed epithelial-myoepithelial carcinoma.
Bonetti and colleagues,[13,44] in 1992 and 1994, suggested that renal angiomyolipoma and clear cell tumor of the lung had in common an unusual epithelioid cell type characterized by clear and acidophilic cytoplasm, immunoreactivity with melanocytic markers, and a perivascular distribution; they proposed the term perivascular epithelioid cell (PEC) to identify this cell.
Rather than metaplasia of the surface epithelium, endometrioid and clear cell tumors may result from retrograde menstruation, with the fallopian tube acting as a conduit for cells to gain access to the peritoneal cavity and the ovarian surface.
CD10 expression in epithelial tissues and tumors of the gynecologic tract: a useful marker in the diagnosis of mesonephric, trophoblastic, and clear cell tumors.
Jones, a research associate at the Johns Hopkins Kimmel Cancer Center, Baltimore, and associates evaluated 18,000 protein-encoding genes in ovarian clear cell tumors from eight patients (Science 2010 [doi:10.
For the study, the scientists evaluated mutations in 18,000 protein-encoding genes in ovarian clear cell tumors from eight patients at Johns Hopkins and from institutions in Taiwan and Japan.
pleomorphic adenoma, myoepithelioma, oncocytoma, mucoepidermoid carcinoma, and clear cell carcinoma) and metastatic clear cell tumors (e.
Glycogen-rich clear cell tumors and mucoepidermoid variants of SPC are uncommon.

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