Its PDZ domains could bind to C-terminal sequences of claudins
and its GUK domains could bind to the C-terminal tail of occludin.
Specific topics include charge-selective claudin
channels, dynamic properties of the tight junction barrier, the regulation of tight junction in human normal pancreatic duct epithelial cells and cancer cells, diverse types of junctions containing tight junction proteins in stratified mammalian epithelia, and the involvement of claudins
in zebrafish brain ventricle morphogenesis.
For example, the RCC marker antigen and CD10 are preferentially expressed in proximal tubules and the corresponding clear cell RCC; S100A, claudins
, and kidney-specific cadherin are preferentially expressed in distal convoluted tubules and corresponding chromophobe RCC and oncocytoma.
are components of tight junctions found between intestinal cells and are involved in creating a permeability barrier so that substances cannot pass from the lumen of the intestine to the blood.
Tight junctions are composed of transmembrane proteins occludin, claudins
and junctional adhesion molecules which intercalate with corresponding proteins from adjacent cells to form the intercellular barrier.
influenzae, to find a down regulation of genes called claudins
that encode proteins key to keeping the spaces between epithelial cells tight.
Osmoregulation and expression of ion transport proteins and putative claudins
in the gill of southern flounder (Paralichthys lethostigma).
The orchestration of occludin, claudins
, catenins and cadherins as players involved in maintenance of the blood-epididymal barrier in animals and humans.
Molecular biologists at Nastech have cloned, expressed, and purified many of the important integral membrane proteins that make up tight junctions, including claudins
, occludin and junctional adhesion molecules.
Occludins and claudins
in tight junction strands: leading or supporting players?
Recent investigations have focused on tight junction proteins, belonging to the claudin
-1 to -27 in humans) and the newly defined group of TAMP (three proteins: occludin, Marvel-D2, and tricellulin).
TJ consists of transmembrane proteins including claudins
, occludin and junction-associated molecules.