clathrin


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clath·rin

(klath'rin),
The principal constituent of a polyhedral protein lattice that coats eukaryotic cell membranes (vesicles) and coated pits and appears to be involved in protein secretion and membrane trafficking. This protein also occurs in synaptic vesicles.
[L. clathri, lattice]

clathrin

a protein of eukaryotic cells occurring in indentations of the plasma membrane. These indentations are known as clathrin-coated pits; see RECEPTOR-MEDIATED ENDOCYTOSIS.

clathrin

a highly conserved, fibrous protein, mol. wt 180,000, which forms a characteristic polyhedral coat on the surface of coated pits and coated vesicles.
References in periodicals archive ?
The coated pits contain the electron dense clathrin protein and other proteins [162].
The team determined that this protein is a specialized form of an omnipresent housekeeping protein called clathrin, which is known to be instrumental in moving proteins between cellular compartments.
Deletion of a putative clathrin binding domain in the C terminal half by site specific mutagenesis abolished TOR's ability to internalize the adenosine transporter.
9) The organism is internalized by clathrin coated pits.
As a result, clathrin mediated endocytosis (CME) has a central role in maintaining cellular homeostasis and function and mis-regulation of endocytic traffic is linked to many human diseases.
Overexpression of MARCH1 in HeLa cells causes CD98 to be trafficked via EEA1 positive compartments and late endosomes rather than clathrin independent endocytosis [46].
Rickettsial outer-membrane protein B (rOmpB) mediates bacterial invasion through Ku70 in an actin, c-Cbl, clathrin and caveolin 2-dependent manner.
Some recently identified genes that also contribute to AD risk include CLU and PICALM (phosphatidylinositolbinding clathrin assembly protein), among others.
Endocytosis of CT may follow one of three pathways: (i) lipid raft/caveolae mediated endocytic pathway, (ii) clathrin mediated endocytic pathway, or (iii) ADP-ribosylation factor 6 (Arf6)-associated endocytic pathway.
endoplasmic reticulum, Golgi apparatus and clathrin coated vesicles [24-26].

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