HES2

(redirected from Class B basic helix-loop-helix protein 40)

HES2

A gene on chromosome 1p36.31 that encodes a DNA-binding repressor of genes that require a basic helix-loop-helix (bHLH) for their transcription. This transcription repression requires the formation of a complex with a co-repressor protein of the Groucho/TLE family. HES2 is expressed in placenta and in cancers of the pancreas, colon, cervix, and head and neck.