Clark level

Clark lev·'el

(klahrk),
the level of invasion of primary malignant melanoma of the skin; limited to the epidermis, I; into the underlying papillary dermis, II; to the junction of the papillary and reticular dermis, III; into the reticular dermis, IV; into the subcutaneous fat, V. The prognosis is worse with each successive deeper level of invasion.

Clark lev·el

(klahrk lev'ĕl)
The level of invasion of primary malignant melanoma of the skin; limited to the epidermis, I; into the underlying papillary dermis, II; to the junction of the papillary and reticular dermis, III; into the reticular dermis, IV; into the subcutaneous fat, V. The prognosis becomes worse with each successively deeper level of invasion.

Clark,

Wallace H., Jr., U.S. dermatopathologist, 1924-1997.
Clark level - the level of invasion of primary malignant melanoma of the skin, recorded by Roman numerals I, II, III, IV, V.
References in periodicals archive ?
Kent, the most significant change from the 2001 guidelines relates to staging, with mitotic rate replacing Clark level of invasion as the second factor predicting melanoma survival in addition to tumor (Breslow) thickness for tumors 1 mm or smaller in thickness.
Moreover, in melanomas with polypoid growth pattern, the tumor can reach a thick Breslow thickness but still be a Clark level III tumor.
We performed a rhomboid flap reconstruction of a 2-cm left cheek defect in a 58-year-old man who had previously undergone wide local excision and sentinel lymph node mapping for a Clark level III melanoma (figure 3, A).
Histopathology reports were reviewed for patients' geographical area, gender, age, ethnic group, tumour site, Clark level of invasion, Breslow thickness (mm), and histogenetic type (when available).
Excisional biopsy was performed and histopathologic examination was consistent with malignant melanoma of Clark level V, Breslow depth 11 mm.
The survival of patients with melanomas of Clark level II was much better than that for patients with tumors at deeper levels (3,4); although the tumor had metastasized for 3 of 36 patients with level II melanomas in the initial study, subsequent studies showed a much superior survival rate of approximately 98% when polypoid melanomas are excluded.
Specifically, 37% of all tumors (but 71% of those that recurred) had a lesional depth exceeding 4 mm, and 33% of all tumors (but 71% of those that recurred) were Clark level V "Perineural invasion was actually seen in quite a few of the tumors [15%], probably more so than conventional SCC," Dr.
Anatomic level has been replaced by mitotic rate in the AJCC 7th edition tables for subclassifying pT1 lesions as T1a or T1b, but in the text and in a table comment of the AJCC chapter, (10) Clark level IV or V is referred to as a tertiary criterion for T1b in cases with no ulceration and "if mitotic rate cannot be determined.
High osteopontin expression was also associated with greater Clark level, tumor thickness, and mitotic index, which are among the key factors in the American Joint Committee on Cancer staging criteria.
In a univariate analysis, Clark level, lymphovascular invasion, vertical growth, biopsy type, and location of the primary rumor on the head, neck, or trunk were not predictive of SLN metastasis.
HEA EADS UP DS UP Gordon nods opener, left, Gordon nods opener, left, before Clark levels and McCall, below
The terracing wise-guys get cracking again when Shotts skipper Robert Clark levels from the spot.