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Clark's level

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Clark's level (klärks)
n.
Any of four levels that mark the invasion of malignant melanoma through the skin layers to the subcutaneous fat layer, each successive level indicating a worsening prognosis.


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The report came back: "Nodular Malignant Melanoma, stage II, Clark's Level IV, with some lymphatic infiltrate.
He remained well with regard to the melanoma until 2005 when, at the age of 69, he had a second primary melanoma removed from his back, Breslow thickness 9mm, Clark's level V, with no ulceration but areas of focal regression were seen.
Breslow's depth of invasion (measured in hundredths of a millimeter) and Clark's level of invasion into the layers of the dermis (papillary dermis, reticular dermis, and subcutaneous layer) are both important components of the diagnosis, as they guide therapy and yield prognostic information.
 
 
 
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