loratadine

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loratadine

 [lah-rat´ah-dēn]
a nonsedating antihistamine (H1 receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria and as a treatment adjunct in asthma; administered orally.

loratadine

Aerius (CA), Alavert, Allertin, Claritin, Claritin RediTabs, Clarityn (UK)

Pharmacologic class: Histamine1-receptor antagonist (second-generation)

Therapeutic class: Antihistamine (nonsedating)

Pregnancy risk category B

Action

Selective histamine1-receptor antagonist. Blocks peripheral effects of histamine release during allergic reactions, decreasing or preventing allergy symptoms.

Availability

Syrup: 1 mg/ml

Tablets: 10 mg

Tablets (rapidly disintegrating): 10 mg

Indications and dosages

Seasonal allergies; chronic idiopathic urticaria

Adults and children ages 6 and older: 10 mg P.O. daily

Children ages 2 to 5: 5 mg P.O. daily

Dosage adjustment

• Renal or hepatic impairment

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:
• renal or hepatic impairment
• elderly patients
• pregnant patients
• children younger than age 2 (safety not established).

Administration

• Give once a day on empty stomach.
• Place rapidly disintegrating tablet on tongue; give with or without water.
• Use rapidly disintegrating tablets within 6 months of opening foil pouch and immediately after opening individual tablet blister.

Adverse reactions

CNS: headache, nervousness, insomnia

EENT: conjunctivitis, earache, epistaxis, pharyngitis

GI: abdominal pain; dry mouth; diarrhea, stomatitis (in children)

Skin: rash, photosensitivity, angioedema

Other: tooth disorder (in children), fever, flulike symptoms, viral infections

Interactions

Drug-food.Any food: increased drug absorption

Patient monitoring

• Watch for adverse reactions, especially in children.
• Assess patient's response to drug.
• Watch for new symptoms or exacerbation of existing symptoms.

Patient teaching

• Advise patient to take exactly as prescribed, once a day on empty stomach.
• Tell patient to report persistent or worsening symptoms.
• Instruct patient to report adverse reactions, such as headache or nervousness.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the foods mentioned above.

loratadine

/lor·at·a·dine/ (lah-rat´ah-dēn) a nonsedating antihistamine used in the treatment of allergic rhinitis, chronic idiopathic urticaria, and asthma.

loratadine

(lôr-ăt′ə-dēn′)
n.
A nonsedating antihistamine, C22H23ClN2O2, used to treat allergic rhinitis and other allergic disorders.

loratadine

[lärat′ädēn]
a nonsedating antihistamine (H1-receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria and as a treatment adjunct in asthma, administered orally.

loratadine

An ANTIHISTAMINE drug used to treat hay fever and other allergic disorders.

antihistamine 

Any substance that reduces the effect of histamine or blocks histamine receptors, usually the histamine 1 (H1) receptor. It is used in the treatment of allergic conjunctivitis and also in the temporary relief of minor allergic symptoms of the eye. Common agents include antazoline sulfate, azelastine hydrochloride, cetirizine, chlorphenamine, emedastine, epinastine hydrochloride, ketotifen, levocabastine, loratadine and olopatadine. See hypersensitivity; mast cell stabilizers.

loratadine

(lərat´ədēn),
n brand name: Claritin;
drug class: antihistamine, H1 histamine antagonist;
action: acts on blood vessels, gastrointestinal system, respiratory system by competing with histamine for H1-receptor site; decreases allergic response by blocking histamine;
uses: seasonal rhinitis, allergy symptoms, idiopathic chronic urticaria.
References in periodicals archive ?
Adrian Morris, Clarityn Rapide's expert consultant from the Surrey Allergy Clinic in London explains: "The countryside with high summer levels of tree and grass pollen was always presumed to be bad for hayfever sufferers, but what most people don't know is that in urban areas, these pollens attach to the diesel exhaust particles from cars.
P-medicine and GSL oral solutions of most of the antihistamines are also available to facilitate this low dosing (ie, half a spoonful for a child), eg, Allerief (chlorphenamine), Benadryl Allergy Oral Syrup (cetirizine), Benadryl for Children Allergy Solution, Clarityn Allergy Syrup (loartidine), Piriteze Allergy Syrup, Zirtek Allergy Solution and Zirtek Allergy Relief for Children (cetirizine).
The Clarityn Allergy Advisory Service has a helpline on 0171 617 0662.
The fact that you have had no response to Clarityn (loratadine) doesn't point toward any of these.
The newer ones like Clarityn, Zirtek and Benadryl are less likely to cause drowsiness and have fewer side effects.
Treatments: Clarityn (non-drowsy, one a day); Piriton (may cause drowsiness) or Anthisan (antihistamine cream).
As are Clarityn Rapide (PS4, from pharmacies and supermarkets) - a melt-in-the-mouth tablet you don't need water to take.
Top 10 brands * BY VALUE 1 Boots Soltan 2 Ambre Solaire 3 Nivea 4 Piz Buin 5 Boots 6 Benadryl 7 Sudocrem 8 Savlon 9 Piriton 10 Clarityn Top 10 retailers * BY VALUE % 1 Boots 45.
UNIT SALES (000S PACKS) W/e 12/5101 19/5/01 26/5/01 Calpol six plus suspension liquid analgesic sugar-free 100ml 6 8 10 Benylin chesty cough 125ml 3 3 3 Clarityn allergy tablets 7s 14 13 23 Nurofen tablets 24s 2.
Modern versions like Clarityn and Zirtek may cause headaches, a skin rash or dry mouth.
I have tried five types of cream plus clarityn and piriton tablets, all to no avail.