loratadine

(redirected from Claritin-d)
Also found in: Dictionary.

loratadine

 [lah-rat´ah-dēn]
a nonsedating antihistamine (H1 receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria and as a treatment adjunct in asthma; administered orally.

loratadine

Aerius (CA), Alavert, Allertin, Claritin, Claritin RediTabs, Clarityn (UK)

Pharmacologic class: Histamine1-receptor antagonist (second-generation)

Therapeutic class: Antihistamine (nonsedating)

Pregnancy risk category B

Action

Selective histamine1-receptor antagonist. Blocks peripheral effects of histamine release during allergic reactions, decreasing or preventing allergy symptoms.

Availability

Syrup: 1 mg/ml

Tablets: 10 mg

Tablets (rapidly disintegrating): 10 mg

Indications and dosages

Seasonal allergies; chronic idiopathic urticaria

Adults and children ages 6 and older: 10 mg P.O. daily

Children ages 2 to 5: 5 mg P.O. daily

Dosage adjustment

• Renal or hepatic impairment

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:
• renal or hepatic impairment
• elderly patients
• pregnant patients
• children younger than age 2 (safety not established).

Administration

• Give once a day on empty stomach.
• Place rapidly disintegrating tablet on tongue; give with or without water.
• Use rapidly disintegrating tablets within 6 months of opening foil pouch and immediately after opening individual tablet blister.

Adverse reactions

CNS: headache, nervousness, insomnia

EENT: conjunctivitis, earache, epistaxis, pharyngitis

GI: abdominal pain; dry mouth; diarrhea, stomatitis (in children)

Skin: rash, photosensitivity, angioedema

Other: tooth disorder (in children), fever, flulike symptoms, viral infections

Interactions

Drug-food.Any food: increased drug absorption

Patient monitoring

• Watch for adverse reactions, especially in children.
• Assess patient's response to drug.
• Watch for new symptoms or exacerbation of existing symptoms.

Patient teaching

• Advise patient to take exactly as prescribed, once a day on empty stomach.
• Tell patient to report persistent or worsening symptoms.
• Instruct patient to report adverse reactions, such as headache or nervousness.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the foods mentioned above.

loratadine

/lor·at·a·dine/ (lah-rat´ah-dēn) a nonsedating antihistamine used in the treatment of allergic rhinitis, chronic idiopathic urticaria, and asthma.

loratadine

(lôr-ăt′ə-dēn′)
n.
A nonsedating antihistamine, C22H23ClN2O2, used to treat allergic rhinitis and other allergic disorders.

loratadine

[lärat′ädēn]
a nonsedating antihistamine (H1-receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria and as a treatment adjunct in asthma, administered orally.

loratadine

An ANTIHISTAMINE drug used to treat hay fever and other allergic disorders.

antihistamine 

Any substance that reduces the effect of histamine or blocks histamine receptors, usually the histamine 1 (H1) receptor. It is used in the treatment of allergic conjunctivitis and also in the temporary relief of minor allergic symptoms of the eye. Common agents include antazoline sulfate, azelastine hydrochloride, cetirizine, chlorphenamine, emedastine, epinastine hydrochloride, ketotifen, levocabastine, loratadine and olopatadine. See hypersensitivity; mast cell stabilizers.

loratadine

(lərat´ədēn),
n brand name: Claritin;
drug class: antihistamine, H1 histamine antagonist;
action: acts on blood vessels, gastrointestinal system, respiratory system by competing with histamine for H1-receptor site; decreases allergic response by blocking histamine;
uses: seasonal rhinitis, allergy symptoms, idiopathic chronic urticaria.
References in periodicals archive ?
The day prior to agency's issuance of the ANDA acceptance for filing letter, we contacted FDA and were informed that no other Paragraph IV ANDA filing had been accepted for a generic version of Claritin-D 12-Hour," commented Larry Hsu, Ph.
A Perrigo spokesman explains that the products are generic equivalents of Claritin-D 12 Hour, Claritin-D 24 Hour and Claritin RediTabs.
We are pleased with our Perrigo alliance and their success in building store brand share of our generic equivalent of Claritin-D 24.
The fall allergy season is here, and Schering-Plough HealthCare Products, the maker of Claritin-D, is educating consumers about important changes in the allergy and cold relief aisle.
The company says it will produce generic versions of the less widely used types of Claritin, including a version of Claritin RediTabs, a quick-dissolving tablet that can be taken without water, and a generic version of Claritin-D, which contains a decongestant.
sales of Claritin-D 24-hour were approximately $200 million for the 12 months ended August 31, 2003.
Claritin made its over-the-counter debut in December 2002 with five formulations, all at prescription strength: once-daily tablets, once-daily tablets that can be taken without water, a syrup for use by children age 2 and over, and 12- and 24-hour formulations of Claritin-D, which contains a decongestant.
In addition, says the company, a fluoroloratadine patent expires in 2008 and a formulation patent for Claritin-D 24 hour expires in 2012.
Under the terms of the agreement, Andrx will receive a license to a relevant patent pertaining to Claritin-D 24 and the lawsuit with respect to such product will be dismissed with prejudice.
to produce three versions of O-T-C loratadine, which a company spokesman says are the generic equivalents of Claritin-D 12 Hour, Claritin-D 24 hour and Claritin RediTabs.
The two original members of the Claritin family, Claritin tablets and Claritin-D 12, have now been joined by three new members, giving us more formulations on the market than anyone else," Kogan continued.
This ruling should close the book on Schering's efforts to block the introduction of our generic versions of Claritin-D 12-hour and Claritin Reditabs," he added.