desloratadine

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Related to Clarinex: Desloratadine, Zyrtec

desloratadine

 [des″lah-rat´ah-dēn]
a nonsedating antihistamine (H1 receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria; administered orally.

desloratadine

Aerius (CA), Clarinex, Clarinex Reditabs, Neoclarityn (UK)

Pharmacologic class: Peripherally selective piperidine, selective histamine1-receptor antagonist

Therapeutic class: Antihistamine (nonsedating, second generation)

Pregnancy risk category C

Action

Suppresses histamine release at peripheral histamine1-receptor sites

Availability

Syrup: 2.5 mg/5 ml

Tablets: 5 mg

Tablets (orally disintegrating): 2.5 mg, 5 mg

Indications and dosages

Seasonal and perennial allergic rhinitis; chronic idiopathic urticaria and allergies caused by indoor and outdoor allergens; pruritus; to reduce number and size of hives

Adults and children ages 12 and older: 5 mg/day P.O.

Children ages 6 to 11: 1 tsp (2.5 mg/5 ml syrup) P.O. once daily

Children ages 12 months to 5 years: ⁄2 tsp (1.25 mg in 2.5 ml syrup) P.O. once daily

Children ages 6 to 11 months: 2 ml (1 mg syrup) P.O. once daily

Dosage adjustment

• Hepatic or renal impairment

Contraindications

• Hypersensitivity to drug, its components, or loratadine

Precautions

Use cautiously in:
• renal or hepatic impairment
• elderly patients
• pregnant or breastfeeding patients
• children younger than age 12 (safety and efficacy not established, except syrup).

Administration

• Give with or without food.

Adverse reactions

CNS: dizziness, drowsiness, fatigue, headache

CV: tachycardia, palpitations

EENT: pharyngitis, dry throat

GI: nausea, dyspepsia, dry mouth

GU: dysmenorrhea

Musculoskeletal: myalgia

Other: flulike symptoms, hypersensitivity reaction

Interactions

Drug-diagnostic tests.Bilirubin, hepatic enzymes: increased values

Skin tests: interference with positive reaction to dermal reactivity indicators

Patient monitoring

• Monitor hepatic and renal function test results.

Patient teaching

• Tell patient he may take drug with or without food.
• Instruct patient to report rapid heartbeat, shortness of breath, rash, persistent flulike symptoms, or muscle ache.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the tests mentioned above.

desloratadine

[des′lärat′ädēn]
a nonsedating antihistamine (H1 receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria. It is administered orally.

desloratadine

A long-acting, low-sedation, ANTIHISTAMINE drug that does not block cardiac potassium channels and is less likely than some second generation antihistamines to have undesirable cardiac effects. It is also less prone to enter the nervous system and produce sedation. A brand name is Neoclarityn.
References in periodicals archive ?
According to IMS Health, the Clarinex Reditabs brand had US sales of about USD5.
15, 2001, that the FDA cited manufacturing deficiencies at its facilities in New Jersey and Puerto Rico, causing the agency to withhold approval of Clarinex.
Clarinex (desloratadine), Zyrtec (cetirizine) Short-acting antihistamines Benadryl Prescription tablets, liquid.
Claritin, Schering-Plough's popular antihistamine, has been over the counter for years; Clarinex, a virtually identical drug from the same maker, is prescription-only.
A number of other major allergy medications, including Pfizer's Zyrtec, Aventis Pharmaceutical's Allegra and Schering-Plough's Clarinex, may convert from prescription status in the not-too-distant future.
Now that Claritin's patent has expired (and genetic competitors are free to make the drug), Schering-Plough is encouraging kids to switch to its new allergy drug, Clarinex, sponsoring soccer tournaments and sports equipment giveaways for inner-city kids--even as consumer groups and medical experts complain that in many cases it's better to keep children away from allergens than to give them drugs.
It makes sense for consumers (and health insurance companies) to prefer the over-the-counter medications when equivalent prescription medications such as Allegra, Clarinex and Zyrtec range in price from $2.
In the case of the blockbuster antihistamine Claritin, Schering-Plough won FDA approval last November to change it from a prescription drug to an over-the-counter product, thus preventing generic competitors from jumping into the prescription market when its patent expired in December; meanwhile, the firm pushed prescription Clarinex, a supposed "improvement" that consists, say the authors, of nothing more than "the molecule into which the body converts Claritin, which accounts entirely for the action of the drug.
The company is sending the discount coupon to all members who have received prescriptions for Claritin, Allegra, Zyrtec, or Clarinex within the past 6 months.
Clarinex costs $15 less per prescription than Allegra and $25 less per prescription than Claritin, according to HealthNet.
Schering-Plough had hoped to extend its exclusive hold over Claritin to 2004 and beyond because of a related patent on a chemical cousin of Claritin, the Clarinex patent.
Schering--desperately attempting to hold on to its customers--has just entered Clarinex into a multimedia advertising face-off with Zyrtec (Pfizer) and Allegra (Aventis), a several-hundred-million-dollar exchange the likes of which may never before have graced the airwaves.