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Related to Clarinex: Desloratadine, Zyrtec


a nonsedating antihistamine (H1 receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria; administered orally.


Aerius (CA), Clarinex, Clarinex Reditabs, Neoclarityn (UK)

Pharmacologic class: Peripherally selective piperidine, selective histamine1-receptor antagonist

Therapeutic class: Antihistamine (nonsedating, second generation)

Pregnancy risk category C


Suppresses histamine release at peripheral histamine1-receptor sites


Syrup: 2.5 mg/5 ml

Tablets: 5 mg

Tablets (orally disintegrating): 2.5 mg, 5 mg

Indications and dosages

Seasonal and perennial allergic rhinitis; chronic idiopathic urticaria and allergies caused by indoor and outdoor allergens; pruritus; to reduce number and size of hives

Adults and children ages 12 and older: 5 mg/day P.O.

Children ages 6 to 11: 1 tsp (2.5 mg/5 ml syrup) P.O. once daily

Children ages 12 months to 5 years: ⁄2 tsp (1.25 mg in 2.5 ml syrup) P.O. once daily

Children ages 6 to 11 months: 2 ml (1 mg syrup) P.O. once daily

Dosage adjustment

• Hepatic or renal impairment


• Hypersensitivity to drug, its components, or loratadine


Use cautiously in:
• renal or hepatic impairment
• elderly patients
• pregnant or breastfeeding patients
• children younger than age 12 (safety and efficacy not established, except syrup).


• Give with or without food.

Adverse reactions

CNS: dizziness, drowsiness, fatigue, headache

CV: tachycardia, palpitations

EENT: pharyngitis, dry throat

GI: nausea, dyspepsia, dry mouth

GU: dysmenorrhea

Musculoskeletal: myalgia

Other: flulike symptoms, hypersensitivity reaction


Drug-diagnostic tests.Bilirubin, hepatic enzymes: increased values

Skin tests: interference with positive reaction to dermal reactivity indicators

Patient monitoring

• Monitor hepatic and renal function test results.

Patient teaching

• Tell patient he may take drug with or without food.
• Instruct patient to report rapid heartbeat, shortness of breath, rash, persistent flulike symptoms, or muscle ache.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the tests mentioned above.


a nonsedating antihistamine (H1 receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria. It is administered orally.


A long-acting, low-sedation, ANTIHISTAMINE drug that does not block cardiac potassium channels and is less likely than some second generation antihistamines to have undesirable cardiac effects. It is also less prone to enter the nervous system and produce sedation. A brand name is Neoclarityn.
References in periodicals archive ?
Food and Drug Administration approval to introduce generic versions of the allergy pill Clarinex, for which Sepracor owns patent rights, and Roche's osteoporosis drug Boniva.
Pursuant to the agreement, Orchid received rights to launch a generic version of the Clarinex brand Reditabs in the U.
chief pharmacy officer at WellPoint, "Claritin is a [preferred] drug, and there's really nothing in the clinical literature that differentiates it from any of the prescription antihistamines, whether it's Clarinex, Allegra, or Zyrtec.
SCHERING-PLOUGH CORPORATION Report for the period ended March 31 (unaudited): GAAP Net Sales by Key Product: (Dollars in Millions) First Quarter 2006 2005 % GLOBAL PHARMACEUTICALS $2,032 $1,846 10 REMICADE 278 220 26 NASONEX 229 183 25 PEG-INTRON 196 170 16 TEMODAR 163 131 25 CLARINEX / AERIUS 160 144 11 CLARITIN RX 101 111 (9) AVELOX 80 73 10 INTEGRILIN 80 75 6 REBETOL 78 64 22 INTRON A 60 73 (18) CAELYX 51 43 18 SUBUTEX 48 51 (6) ELOCON 34 41 (17) CIPRO 25 37 (32) Other Pharmaceuticals 449 430 4 CONSUMER HEALTH CARE 311 330 (6) OTC 153 162 (6) OTC CLARITIN 111 116 (4) Foot Care 83 84 (2) Sun Care 75 84 (10) ANIMAL HEALTH 208 193 8 CONSOLIDATED NET SALES $2,551 $2,369 8 NOTE: Additional information about U.
CLARINEX is the only branded prescription allergy treatment available in this diverse variety of formulations.
The double-blind, placebo-controlled study of 534 patients assessed the effectiveness of CLARINEX in relieving symptoms of SAR and an analysis of morning symptom scores, which reflect symptoms 24 hours after the last dose of treatment.
Our study forecasts sales of 26 products, including these brands: -- Nasonex -- Allegra/Allegra-D/Allegra OTC -- Zyrtec/Zyrtec D -- Claritin/Claritin OTC -- Astepro -- Avamys/Veramyst -- Xyzal -- Allelock -- Staloral -- Clarinex Discover how high revenues can go.
UMass Medical School has had recent success bringing other ideas to market, most notably cytogam, a drug licensed to CSL Behring that blocks cytomegalovirus disease associated with organ transplantation; Clarinex, that ubiquitous allergy medicine; and through the medical device company Reflectance Medical Inc.
In 2009, Merck's Clarinex (desloratadine) had a quarter of Claritin's (loratadine) peak sales, having launched after generics.
judge's approval of a $165 million settlement to resolve lawsuits over alleged fraudulent statements to investors about the Clarinex allergy medicine.
Schering-Plough, developer of the Claritin and Clarinex allergy drugs, has been working on a turnaround program since Claritin lost patent protection in 2002, leading to three years of losses.
Silver: Prescription Kit, Clinique, submitted by Hirschhorn and Young Graphics; Bronze: Clarinex Self Care Center, Schering Pharmaceuticals, submitted by Sunbelt Dimensional, and Honorable mention: 2004 NJPEC Awards Program, NJPEC, submitted by Sunbelt Dimensional.