isotretinoin

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isotretinoin

 [i″so-tret´ĭ-no-in]
a synthetic form of retinoic acid (13-cis-retinoic acid), used orally to clear cystic and conglobate acne.

i·so·tret·i·noin

(ī'sō-tret'i-noyn),
A retinoid used to treat severe recalcitrant cystic acne; a known human teratogen.

isotretinoin

/iso·tret·i·noin/ (i″so-tret´in-o-in) a synthetic form of retinoic acid, used orally to clear cystic and conglobate acne.

isotretinoin

(ī′sō-trĕt′n-oin′)
n.
A synthetic isomer of retinoic acid that inhibits sebaceous gland secretion and is used in the treatment of severe nodular acne. It can cause birth defects if taken during pregnancy.

isotretinoin

[-trətin′ō·in]
an antiacne agent.
indication Subject to significant restrictions, it is prescribed for the treatment of severe cystic acne.
contraindications Pregnancy or sensitivity to the medication or any of its components prohibits its use.
adverse effects A powerful teratogen, young females must be thoroughly educated about the risk of pregnancy and are often placed on birth control pills. The most serious adverse effects to users are epistaxis, cheilitis, conjunctivitis, paresthesia, dizziness, and serum lipid and hematologic disturbances. It may also lower bone mineral density, a consideration for those participating in sports. Some patients become severely depressed or psychotic, which can make them aggressive or suicidal.

isotretinoin

Retinoic acid, 13-cis retinoic acid A retinoid used to treat acne and psoriasis and may ↓ tumor development Side effects Inflammation of skin and mucosa, hepatitis

i·so·tret·i·no·in

(ī'sō-tret'i-nō'in)
A retinoid used to treat severe recalcitrant cystic acne; a known human teratogen.

isotretinoin

A RETINOID drug used to treat ACNE. The oral preparation is used under strictly controlled conditions to exclude pregnancy because of the known risks to the fetus. Brand names are Roaccutane, and, for external use Isotrex and Isotrexin.

Isotretinoin

A powerful vitamin A derivative used in the treatment of acne. It can promote scarring after skin resurfacing procedures.
Mentioned in: Acne, Skin Resurfacing

i·so·tret·i·no·in

(ī'sō-tret'i-nō'in)
A retinoid used to treat severe recalcitrant cystic acne; known human teratogen.

isotretinoin

(ī´sōtret´inoin),
n brand name: Accutane;
drug class: retinoic acid isomer, vitamin A derivative;
action: decreases sebum secretion, improves cystic acne;
uses: severe recalcitrant cystic acne.

isotretinoin

a synthetic form of retinoic acid (13-cis-retinoic acid), used in dermatology for the treatment of disorders of keratinization. It is a potent teratogen.
References in periodicals archive ?
5 Teva: Claravis Revenue ($m), AGR (%), CAGR (%), 2012-2024 Table 7.
Our study forecasts sales of 23 products, including these brands: -- Cubicin -- Zyvox -- Humira -- Enbrel -- Stelara -- Claravis -- Epiduo -- Protopic.
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The Company will now market the full line of Isotretinoin product strengths, including Claravis 10 mg, 20 mg, 30 mg and 40 mg capsules.
Claravis Capsules, 30 mg will compete with Ranbaxy's Sotret(R) (Isotretinoin) Capsules USP, 30 mg that had total annual sales of approximately $15 million for the most recent twelve months ending March 2006, based on IMS data.
Other brands of isotretinoin include Amnesteem, Claravis and Sotret.
Once the program is fully implemented in December 2005, Accutane, Amnesteem, Claravis and Sotret can only be prescribed by prescribers who are registered and activated with the iPLEDGE program.
Isotretinoin is sold by Barr Pharmaceuticals as Claravis, Mylan/Bertek, a wholly owned subsidiary of Mylan Laboratories Inc.
Food & Drug Administration (FDA) approved the Company's application to manufacture and market Claravis in April 2003.
The Company will promote Claravis to dermatologists using its sales force that currently markets Trexall(TM) (Methotrexate Tablets, USP).
With the approval of Claravis, the Company demonstrates our ability to successfully develop complex generic products," said Bruce L.
Barr has implemented a comprehensive education, risk assessment and management program for patients, pharmacists and physicians that includes, but is not limited to, a toll free registration program for prescriber registration and education, a website for healthcare professionals and patients, patient education materials designed to inform patients about the risks associated with use of Claravis, and a pregnancy prevention program.