Clara cell


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Cla·ra cell

(klahr'ah),
a rounded, club-shaped, nonciliated cell protruding between ciliated cells in bronchiolar epithelium; believed to be secretory in function.

Clara cell

A cuboidal epithelial cell found in the lining of the terminal and the respiratory bronchioles of the lungs. Clara cells are nonciliated, and they secrete surfactant, like the type II alveolar epithelial cells found deeper in the bronchial tree.
See also: cell

Clara cell

(klăr′ă, klah′ră)
[Max Clara, Austrian anatomist, 1899–1937]
One of the secreting cells in the surface epithelium of the bronchioles. These cells, along with goblet cells, provide secretions for the respiratory tract. The secretion is a mucus-poor protein that coats the epithelium.

Clara,

Max, Austrian anatomist, 1899–.
Clara cell - a rounded, club-shaped, nonciliated cell protruding between ciliated cells in bronchiolar epithelium; believed to be secretory in function. Synonym(s): bronchiolar exocrine cell
Clara hematoxylin

Clara cell

nonciliated, secretory bronchiolar epithelial cells; function as stem cells for repair in the bronchioles and can divide into ciliated or nonciliated bronchiolar cells.
References in periodicals archive ?
Naphthalene cytotoxicity to differentiating Clara cells in neonatal mice.
Elevated susceptibility to 4-ipomeanol cytotoxicity in immature Clara cells of neonatal rabbits.
Acute injury to differentiating Clara cells in neonatal rabbits results in age-related failure of bronchiolar epithelial repair.
Clara cell protein in serum and bronchoalveolar lavage.
Clara cell protein as a biomarker for ozone-induced lung injury in humans.
Diurnal variation in serum levels of Clara cell protein (CC16) in humans [Abstract].
Effects of nitrogen dioxide exposure on Clara cell proliferation and morphology.
Clara cell protein (CC-16) and surfactant-associated protein A (SP-A) in asbestos-exposed workers.
Clara cell protein (CC-16) induces a phospholipase A2-mediated inhibition of fibroblast migration in vitro.
Quantification of Clara cell protein in rat and mouse biological fluids using a sensitive immunoassay.
Because CC16 is synthesized and secreted almost exclusively by the lung Clara cells, its elevation in serum can be explained only by assuming an increased intravascular leakage of the protein across the lung epithelial barrier (5-7,16).