To investigate, researchers used a mouse model infected with Citrobacter rodentium
, the mouse equivalent of an E.
The following nonpathogenic strains were used for reference experiments: Escherichia coli DH5-Alpha (DH5[+ or -]), enteropathogenic Escherichia coli (EPEC) E2348/69, Citrobacter rodentium
DBS 13 (Citrobacter DBS 13) and Enterobacter cloacae.
sup], Experiments in germ-free mice demonstrated that gut microbiota plays a role in clearing the pathogenic bacterium Citrobacter rodentium
and the clearance was found to be mediated by the enhanced glycan acquisition capabilities of the transferred bacteria.
However, it has been demonstrated with Citrobacter rodentium that secretory IgA is not necessary for preventing bacterial colonization in mice using intimin as a vaccine antigen.
Intimin-specific immune responses prevent bacterial colonization by the attaching-effacing pathogen Citrobacter rodentium.
2006) observed that infection with Citrobacter rodentium
induced anxiety-like behaviors via vagal sensory regulation.
Attaching and effacing pathogens include enterohemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC, respectively) and Citrobacter rodentium
Consequences of Citrobacter rodentium
infection on enteroendocrine cells and the enteric nervous system in the mouse colon.
The disruption of gut microbiota that facilitates gut colonization has been demonstrated in murine models infected with Citrobacter rodentium
and Salmonella enterica serovar Typhimurium (13).
translocated intimin receptor (Tir) is an essential virulence factor needed for actin condensation, intestinal colonization and colonic hyperplasia in mice.
Other pathogens displaying similar histopathologic features include Hafnia alvei, Citrobacter rodentium