SGK3

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SGK3

A gene on chromosome 8q12 that encodes a serine/threonine-protein kinase involved in regulating various ion channels and membrane transporters involved in cell growth, survival and proliferation. It is highly expressed in the pancreas, kidneys, liver, heart and brain.

SGK3 upregulates:
• Na+ channels—e.g., SCNN1A/ENAC and SCN5A;
• K+ channels—e.g., KCNA3/Kv1.3, KCNE1, KCNQ1 and KCNH2/HERG;
• Amino acid transporters—e.g., SLC1A5/ASCT2 and SLC6A19;
• Epithelial Ca2+ channels—e.g., TRPV5 and TRPV6;
• Chloride channel—e.g., BSND
• Creatine transporter—e.g., SLC6A8;
• Glutamate transporter—e.g., SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5;
• Glutamate receptors—e.g., GRIA1/GLUR1 and GRIK2/GLUR6;
• Na+-dependent phosphate cotransporter—e.g., SLC34A2/NAPI-2B;
• Na+/dicarboxylate cotransporter—e.g., SLC13A2/NADC1;
• Na+/H+ exchanger—e.g.,  SLC9A3/NHE3; and
• Na+/K+ ATPase.
References in periodicals archive ?
The Cisk Lager range has won a number of worldwide brewing awards.
Simonds Farsons Cisk, one of the Mediterranean's top breweries, is well known to the 750,000 British holidaymakers who visit the island every year.
Cisk Export Premium Lager is a bottom-fermented beer with a light golden colour and a lively, dense, white head.
Other beers in the range include Cisk XS Extra Strong Lager, Hop leaf Extra and Farsons Strong Ale.
my favourite restaurant was Ta Ricardo in Victoria, where a traditional feast comprised vegetable soup with locally-baked bread, a platter containing capers, sheep cheese, olives, sun-dried tomatoes and salad, followed by fresh ravioli, all washed down with Cisk beer,.
After all this culture you can then reward yourself by dropping into one of the city's cosy bars for a glass of cooling Cisk, the local lager.
This summer, savour the taste of Cisk Export, the world-famous lager from Malta.
Cisk Export has maintained its commitment to the principles started when Simonds--later Courage--set up the brewery in the 1880s.
Retailers stocking Cisk Export are responding to the phenomenal growth in demand far premium bottled Mediterranean lagers.
The celebration was properly sealed 12 hours later at a seaside Maletese bar, with pints of Cisk - another fine local brew - and an expensive bottle of champagne idling in its ice bucket.
Nicola was delighted to discover they were staying at her hotel, and joined them for a few of the local beers, called Cisk, and a gossip - although, sadly, Brad wasn't there