ciprofloxacin

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Related to Cipro xr: ciprofloxacin, Ciproxin

ciprofloxacin

 [sip″ro-flok´sah-sin]
a quinolone antibacterial agent effective against many gram-positive and gram-negative bacteria, including some strains resistant to other agents such as penicillins.

ciprofloxacin

/cip·ro·flox·a·cin/ (sip″ro-flok´sah-sin) a synthetic antibacterial effective against many gram-positive and gram-negative bacteria; used as the hydrochloride salt.

ciprofloxacin

(sĭp′rō-flŏk′sə-sĭn)
n.
A semisynthetic analog of fluoroquinolone that is administered orally and has a broad spectrum of antibiotic activity.

ciprofloxacin

Cipro® Antibiotics A broad-spectrum–GNRs, staphylococci, fluoroquinolone with limited activity against streptococci, anaerobes Indications Acute sinusitis, acute exacerbation of chronic bronchitis, UTI, acute cystitis in ♀, bacterial prostatitis, intra-abdominal infection, skin, bone and joint infection, infectious diarrhea, typhoid fever, gonorrhea Adverse effects GI pain, N&V, diarrhea, seizures, rash, photosensitivity. See Fluoroquinolone.

ciprofloxacin

A fluoroquinolone antibiotic used to treat urinary infections and, as eye drops, for the treatment of corneal ulcers. The drug acts by binding to the enzyme gyrase. Mutations lead to an alteration in the structure of this enzyme leading to antibiotic resistance. Current research suggests the possibility of preventing this process. The drug is on the WHO official list. Brand names are Ciproxin and Ciloxan.

ciprofloxacin

; Ciproxin quinolone antibacterial agent active against Gram-positive and Gram-negative bacteria, Pseudomonas and some mycobacteria

antibiotic 

1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.

ciprofloxacin,

n brand name: Cipro;
drug class: fluoroquinolone antiinfective;
action: a broad-spectrum bactericidal agent that inhibits enzyme deoxyribonucleic acid (DNA) gyrase needed for replication of DNA;
uses: adult urinary tract infection, uncomplicated gonorrhea, typhoid fever; effective against some periodontal organisms.

ciprofloxacin

a fluoroquinolone antibiotic with particularly good activity against gram-negative bacteria, including Enterobacteriaceae and Pseudomonas aeruginosa. It is used mainly in urinary tract infections.
References in periodicals archive ?
Cipro XR is indicated for the treatment of uncomplicated urinary tract infections, complicated urinary tract infections and acute uncomplicated pyelonephritis, or kidney infection due to susceptible strains of indicated organisms.
The safety and effectiveness of Cipro XR in children, adolescents less than 18 years of age, pregnant women and lactating women have not been established.
Antacids containing magnesium, aluminium, calcium, or other products containing metal cations, should be taken 2 hours after or 6 hours before oral administration of Cipro XR.
Bacteriologic eradication (evaluated 5 to 11 days post-therapy) was achieved in 89% of patients with cUTI treated with once-daily Cipro XR and 81% of patients treated with conventional twice-daily Cipro.
Clinical cure (evaluated 5 to 11 days post-therapy) was observed in 96% of cUTI patients treated once a day with Cipro XR 1000mg, compared with 91% of patients receiving the traditional Cipro 500mg twice daily.
Cipro XR is indicated for the treatment of uncomplicated urinary tract infections (acute cystitis) caused by Escherichia coli, Proteus mirabilis, Enterococcus faecalis, or Staphylococcus saprophyticus (a); complicated urinary tract infections caused by Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, Proteus mirabilis, or Pseudomonas aeruginosa (a), and acute uncomplicated pyelonephritis caused by Escherichia coli.
Cipro XR should be administered at least 2 hours before or 6 hours after antacids containing magnesium, aluminium, calcium, or other products containing metal cations.
The primary endpoint of the study, which compared 500 mg Cipro(R) XR, given once-daily over three days, to the conventional twice-daily dose (250 mg) of Cipro(R) (ciprofloxacin HCl), was to demonstrate that treatment with Cipro XR was not inferior to treatment with Cipro.
Lawrence Posner, Senior Vice President and Worldwide Head, Regulatory Affairs, Bayer Corporation, "This study showed that Cipro XR was as effective and well-tolerated as twice-daily Cipro for the treatment of uncomplicated UTIs.
Bayer Corporation submitted a NDA to the FDA in October 2002 to market once daily Cipro XR at a different dosage strength for the treatment of complicated UTIs.
CIPRO XR is indicated solely for the treatment of uncomplicated urinary tract infections (acute cystitis) caused by Escherichia coli, Proteus mirabilis, Enterococcus faecalis, or Staphylococcus saprophyticus(a).