cilastatin


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cilastatin

 [si″lah-stat´in]
an enzyme inhibitor used with imipenem to decrease the metabolism of imipenem in the kidneys and increase its concentration in the urine; administered as the sodium salt.

cilastatin

/ci·la·stat·in/ a dipeptidase inhibitor used with imipenem to decrease the metabolism of imipenem in the kidneys and increase its concentration in the urine; administered as the sodium salt.

cilastatin

A drug used in combination with the beta-lactam antibiotic imipenem (carbapenem) to prevent its degradation in the kidneys so that its action can be prolonged. A brand name for the combination is Primaxin IV.

cilastatin

an inhibitor of dehydropeptidase I, an enzyme found in renal tubules. Used in association with the antibiotic, imipenem, to prevent its inactivation.
References in periodicals archive ?
Imipenem + Cilastatin Sodium, has been shown in studies of 1 9 2 0 Japan and USA , as very active against Staphylococcus aureus.
Fresenius Kabi Company APP Pharmaceuticals Inc on Wednesday announced plans to launch both Imipenem and Cilastatin for Injection, USP and Meropenem for Injection, USP in the US.
Doripenem does not require the addition of cilastatin, and has a lower seizure potential compared to imipenem.
The patient was placed on IV metronidazole, imipenem, and cilastatin, postoperatively.
Comparative inactivation of isepamicin, amikacin, and gentamicin by nine beta-lactam and two beta-lactamase inhibitors, cilastatin and heparin.
Meropenem can be used as a single agent; however, imipenem must be used in conjunction with the compound cilastatin.
of Total patients number of who used the patients = 50 particular antibiotics Third generation Cefixime 3 14 (28%) cephalosporins Ceftriaxone 8 Cefoperazone 1 Cefotaxime 2 Second generation Cefuroxime 2 2 (4%) cephalosporins First generation Cefadroxil 1 1 (2%) cephalosporins Aminoglycosides Amikacin 2 2 (4%) Fluoroquinolones Ofloxacin 2 16 (32%) Ciprofloxacin 9 Levofloxacin 5 Penicillins Cloxacillin 1 8 (16%) Piperacillin tazobactam 5 Amoxicillin clavulanate 2 Carbapenems Meropenem 1 3 (6%) Imipenem / cilastatin 2 Macrolides Azithromycin 2 2 (4%) Nitroimidazoles Metronidazole 8 8 (16%)
Electronic auction: auction in electronic form on the right to conclude a contract for the supply of a medicinal product: imipenem + cilastatin
Imipenem/ cilastatin (25 mg 4x/d) and amikacin (15 mg 2x/d) were given for 2 days.
Additional Patient Assistance Programs -- There are separate patient assistance programs for a number of other prescription medicines, including CANCIDAS(R) (caspofungin acetate) for Injection, CRIXIVAN(R) (indinavir sulfate) Capsules, EMEND(R) (aprepitant), INVANZ(R) (ertapenem for injection), PRIMAXIN(R) (imipenem and cilastatin for injectable suspension) and PRIMAXIN(R) (imipenem and cilastatin for injection).
Tenders are invited for Imipenem 500Mg With Cilastatin 500Mg Inj In Vial
Tenders are invited for Each Vial Contains Imipenem 500 Mg Plus Cilastatin 500 Mg In Vial Only Quotes Its Brand Name Formulation Life