If this becomes known, he observes, "then a whole host of pharmacological agents that act on cells that produce chymase
will become useful in treating EB.
Tryptase and chymase enzyme activity in the MCG preparation was measured as described previously (17).
Tryptase and chymase are the predominant proteases present in MCGs.
Mast cell chymase and tryptase in abdominal aortic aneurysm formation.
Chymase mediates mast cell-induced angiogenesis in hamster sponge granulomas.
Selective conversion of big endothelins to tracheal smooth muscle-constricting 31-amino acid-length endothelins by chymase
from human mast cells.
2 million increase in revenue and net interest income for the first quarter compared to the same period in 1994 was primarily due to (i) increased revenues from the Amgen and Pharmacia collaborations entered into in 1993 for the development of small molecule mimetics of erythropoietin and human growth factors, respectively and (ii) revenues from the company's collaborative agreement with Bayer AG, entered into in November, 1994, for the development of inhibitors of tryptase and chymase
Arris' inflammation program focuses on development of novel therapeutics based on inhibiting tryptase and chymase
NASDAQ:ARRS) Monday announced a five-year collaborative agreement with Bayer, AG, Leverkusen, Germany, covering the company's inflammation program including therapeutic and diagnostic use for tryptase, chymase and their inhibitors.
After an extensive evaluation, Bayer has agreed with us that our program focused on the inhibition of tryptase and chymase may offer an important new approach to the development of therapeutics for asthma, rhinitis and other inflammatory diseases.
Arris's inflammation program focuses on development of novel therapeutics based on inhibiting tryptase and chymase.
Dipeptidyl peptidase I is essential for activation of mast cell chymases
, but not tryptases, in mice.