Churg-Strauss syndrome


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Churg-Strauss syndrome

 [cherg strous]
a form of systemic necrotizing vasculitis in which there is prominent lung involvement with severe asthma, eosinophilia, and granulomatous reactions. If present, skin lesions consist of tender subcutaneous nodules and bruiselike spots. Called also allergic granulomatosis, allergic granulomatous angiitis, and Churg-Strauss vasculitis.

Churg-·Strauss syn·drome

(chŭrg strows),
asthma, fever, eosinophilia, and varied symptoms and signs of vasculitis, primarily affecting small arteries, with vascular and extravascular granulomas.

Churg-Strauss syndrome

[churg′strous′]
Etymology: Jacob Churg, twentieth-century American pathologist; Lotte Strauss, twentieth-century American pathologist
a form of systemic necrotizing vasculitis in which there is prominent lung involvement with severe asthma, eosinophilia, and granulomatous reactions. If present, skin lesions consist of tender subcutaneous nodules and bruiselike spots. The cause is unknown. See also vasculitis.

Churg-Strauss syndrome

An autoimmune vasculitis of small to medium blood vessels with hypereosinophilia arising in a background of asthma and allergic rhinitis, which may be accompanied by tissue eosinophilia, peripheral neuropathy, gastrointestinal necrosis, cardiac lesions, and renal disease. Skin lesions are common in the form of purpura, erythema, urticaria and nodules arising on the scalp and/or extremities.

Churg-Strauss syndrome

Allergic granulomatosus & angiitis Internal medicine A small vessel vasculitis characterized by eosinophil-rich and granulomatous inflammation of the respiratory tract, formation of ANCA and necrotizing vasculitis of small-to-medium-sized vessels associated with asthma, edema. See Small vessel vasculitis, Systemic vasculitis.

Churg-Strauss syndrome

A rare form of blood vessel inflammation (vasculitis) that is almost invariably accompanied by severe ASTHMA. The cause is unknown and although the condition responds well to treatment with steroids or immunosuppressive drugs, the asthma usually persists. The syndrome is distinct from other vasculitides. There are suspicions that it may possibly be caused by certain drugs used to treat asthma, especially antileukotriene drugs.

Churg,

Jacob, Polish-born U.S. pathologist, 1910–.
Churg-Strauss syndrome - asthma, fever, eosinophilia, and varied symptoms and signs of vasculitis, primarily affecting small arteries, with vascular and extravascular granulomas. Synonym(s): allergic granulomatosis; allergic granulomatous angiitis; Strauss-Churg-Zak syndrome

Strauss,

Lotte, U.S. pathologist, 1913-1985.
Churg-Strauss syndrome - see under Churg
Strauss-Churg-Zak syndrome - Synonym(s): Churg-Strauss syndrome

Zak,

Frederick G., U.S. physician.
Strauss-Churg-Zak syndrome - Synonym(s): Churg-Strauss syndrome
References in periodicals archive ?
Serum biomarkers are similar in Churg-Strauss syndrome and hypereosinophilic syndrome.
Information on patient age, gender, drugs dispensed, diagnoses, and procedures was obtained from automated databases, and cases of Churg-Strauss syndrome were identified through the databases and confirmed through chart reviews.
Churg-Strauss syndrome is a small-vessel, systemic vasculitis that can result in eosinophilia, vasculitic rash, worsening pulmonary symptoms, cardiac complications.
Churg-Strauss syndrome (CSS) is defined by the American College of Rheumatology (ACR) as eosinophilic vasculitis in addition to one or more of the following: asthmatic airway obstruction, a differential leukocyte count with more than 10% eosinophils, migratory or transient pulmonary infiltrates, sinusitis and mononeuropathy, or polyneuropathy.
The antineutrophil cytoplasmic antibodies (ANCA)-associated small vessel vasculitides include Wegener's granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis (MPA), and the renal limited form of MPA, also known as pauci-immune or idiopathic crescentic glomerulonephritis.
The most common side effect is headache; rare cases of Churg-Strauss syndrome have been reported, mostly in asthmatic patients on steroids, however.
Necrotizing vasculitides associated with antineutrophil cytoplasmic antibodies (ANCAs) include granulomatous polyangiitis (GPA), formerly known as Wegener granulomatosis, and Churg-Strauss syndrome.
Churg-Strauss syndrome successfully treated with rituximab.
Vasculitis: Wegener granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis, polyarteritis nodosa, and Takayasu arteritis.