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chronic inflammatory demyelinating polyneuropathy

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chronic inflammatory demyelinating polyneuropathy (CIDP),
a slowly progressive autoimmune neurologic disorder with demyelination of the peripheral nerves and nerve roots, characterized by progressive weakness and impaired sensory function (loss of reflexes) in the limbs and enlargement of the peripheral nerves and usually by elevated protein in the cerebrospinal fluid. It occurs most commonly in young adults, particularly males. Presenting symptoms often include tingling or numbness of the digits, weakness of the limbs, hyporeflexia or areflexia, fatigue, and abnormal sensations. It is similar to Guillain-Barré syndrome but has a slower onset and lasts much longer.


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Patients with chronic inflammatory demyelinating polyneuropathy (CIDP) experience proximal- and distal-extremity weakness, sensory loss, and often hyporeflexia or areflexia.
Chronic peripheral neuropathy encompasses several diagnoses, with chronic inflammatory demyelinating polyneuropathy (CIDP) being the most prevalent.
The inaugural Talent grants will fund a variety of studies ranging from basic cellular mechanisms by which IGIV mediates immune response, to a multicenter clinical registry to establish the efficacy of IGIV in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) who do not meet normal diagnostic criteria.
 
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