precancer(redirected from Chromosome breakage syndromes)
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Related to Chromosome breakage syndromes: chromosomal instability syndromes
a condition that tends to become malignant (see cancer). adj., adj precan´cerous.
A lesion from which a malignant neoplasm is believed to develop in a significant number of instances, and that may or may not be recognizable clinically or by microscopic changes in the affected tissue.
A precancerous condition.
precancerPremalignant, preneoplasia Any of a broad group of conditions with a malignant predisposition; epithelial precancers may be
1. Glandular–eg, adenomatous hyperplasia–endometrium and adenomatous polyps–colon, stomach, which evolve towards adenocarcinoma of their respective organs or.
2. Squamous–eg, dysplasia of the uterine cervix or other urogenital mucosae; premalignant lesions of mesenchymal origin include prelymphoma and 'presarcoma'–an ad hoc coinage, the latter of which may be due to predisposing factors–eg, osteosarcoma may arise in Paget's disease of bone, radiation, hereditary multiple exostoses, polyostotic fibrous dysplasia, enchondroma, Maffucci's enchondromatosis; osteosarcomas may be induced experimentally by various trauma–chemical–eg, turpentine, mechanical– eg, local pressure, indwelling foreign bodies, ischemia–eg, vessel clamping. Cf Preneoplastic state. See Fragile X syndrome, Hereditary neoplasms, Premalignancy.
Chromosome breakage syndromes Bloom syndrome, Fanconi syndrome
Genodermatoses Albinism, dyskeratosis congenita,epidermodysplasia verruciformis, polydysplastic epidermolysis bullosa, Werner syndrome, xeroderma pigmentosa
Hamartomatous syndromes Multiple exostoses, neurofibromatosis, Peutz-Jegher syndrome, tuberous sclerosis, von Hippel-Lindau syndrome
Immunodeficiency syndromes Ataxia-telangiectasia, Wiskott-Aldrich syndrome, X-linked agammaglobulinemia
A lesion from which a malignant neoplasm is believed to develop in a significant number of instances, and which may or may not be recognizable clinically or by microscopic changes in the affected tissue.