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balanced translocation |
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balanced translocation, the transfer of segments between nonhomologous chromosomes in such a way that the configuration and total number of chromosomes change but each cell contains the normal amount of diploid or haploid genetic material. Usually the long arm of an acrocentric chromosome is transferred to another chromosome, and the small fragment containing the centromere is lost, leaving only 45 chromosomes. A person with a balanced translocation is phenotypically normal but may produce children with trisomies. Compare reciprocal translocation, robertsonian translocation. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Peripheral PNETs share a common immunohistochemical staining profile and a unique chromosomal translocation t(11;22)(q24;q12). The bcl-2 gene was originally identified through studies of the t(14:18) chromosomal translocation associated with human follicular B-cell lymphoma (1-3). New World isolates have a distinct chromosomal translocation and an episomal variation in the open reading frame (ORF) 470 DNA sequence that distinguishes them from the other isolates tested. |
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