balanced translocation

(redirected from Chromosomal translocation)
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bal·anced trans·lo·ca·tion

translocation of the long arm of an acrocentric chromosome to another chromosome; an individual with a balanced translocation has a normal diploid genome and is clinically normal but has a chromosome count of 45 and as a result of asymmetric meiosis may have children lacking the genes on the translocated segment or have them in trisomy.

balanced translocation

the transfer of segments between nonhomologous chromosomes in such a way that the configuration and total number of chromosomes change, but each cell contains the normal amount of diploid or haploid genetic material. Usually the long arm of an acrocentric chromosome is transferred to another chromosome, and the small fragment containing the centromere is lost, leaving only 45 chromosomes. A person with a balanced translocation is phenotypically normal but may produce children with trisomies. Compare reciprocal translocation, robertsonian translocation.

bal·anced trans·lo·ca·tion

(bal'ănst tranz-lō-kā'shŭn)
Translocation of the long arm of an acrocentric chromosome to another chromosome; a person with a balanced translocation has a normal diploid genome and is clinically normal but has a chromosome count of 45 and as a result of asymmetric meiosis may have children lacking the genes on the translocated segment or having them in trisomy.
References in periodicals archive ?
Sarcoma is the most common type of cancer in pediatric patients and defining the type of chromosomal translocation helps in classification, predicting clinical course and therapy.
It proves that phenotypically normal embryos originating from a chromosomal translocation carrier may be carrying chromosomal imbalances.
Little Hugh Murphy, of Sheldon, is thought to be the only person in the world with chromosomal translocation.
Chronic myelogenous leukemia is diagnosed by demonstrating chromosomal translocation involving the BCR-ABL genes: t(9;22).
Acute promyelocytic leukemia with the pseudo-Chediak-Higashi anomaly and molecular documentation of t(15;17) chromosomal translocation.
For example," said Kadoch, "a type of mutation called a chromosomal translocation in the gene encoding one of these newly identified subunits, SS18, is known to be the hallmark of a cancer called synovial sarcoma.
Bruce Ledoux created Guardian Angel Motorsports after his son, Colin, was born with an unbalanced chromosomal translocation.
It is a variation of AML that frequently exhibits a typical chromosomal translocation.
5) The myxoid variant, which is characterized by the chromosomal translocation t(12;16) (q13;p11), is a lobulated soft-tissue tumor composed of slender, hyperchromatic spindle cells and signet-ringlipoblasts, a plexiform vascular pattern, and a myxoid matrix.
For example, the development of the drug imatinib (Gleevec)-one of the most successful targeted cancer therapies to date-stems directly from Rowley's work on the chromosomal translocation associated with CML.
The chromosomal translocation t(15;17) results in PML/RAR [alpha] fusion gene, t(8;21) results in AML1/ETO fusion gene and Inv 16 generates CBF [beta]/MYH11 fusion gene.
The chromosomal translocation results in a fusion between RAR [alpha] and another gene whose product is 'PML', generating a fusion product PML-RAR [alpha] , a chimaeric oncoprotein that has been extensively studied over the last 10 years.

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