mosaicism

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mosaicism

 [mo-za´ĭ-sizm]
the presence in an individual of cells derived from the same zygote, but differing in chromosomal constitution.

mo·sa·i·cism

(mō-zā'i-sizm), [MIM*158250]
Condition of being mosaic (2).

mosaicism

/mo·sa·i·cism/ (mo-za´ĭ-sizm) in genetics, the presence in an individual of two or more cell lines that are karyotypically or genotypically distinct and are derived from a single zygote.

mosaicism

(mō-zā′ĭ-sĭz′əm)
n.
A condition in which tissues of genetically different types occur in the same organism.

mosaicism

[mōzā′isiz′əm]
Etymology: L, Musa, goddess of the arts
(in genetics) a condition in which an individual or an organism that develops from a single zygote has two or more cell populations that differ in genetic constitution. Most commonly seen in humans is a variation in the number of chromosomes in the cells, which may involve either a particular autosome, such as in Down syndrome, or the sex chromosomes, such as in Turner's syndrome and Kleinfelter's syndrome. See also mosaic, sex chromosome mosaic.

mosaicism

The phenotype of a multicelled organism, which is composed of cells expressing different genotypes; for instance, women are functionally mosaic due to the X chromosome genes expressed. Mosaicism due to mutation is less common.

mo·sa·i·cism

(mō-zā'i-sizm)
Condition of being mosaic (2).

mosaicism

The state in which two or more genetically different types of cell occur in the same individual. Although the cells are all derived from the same fertilized egg, they do not all possess the same number of chromosomes. In about 1% of cases of DOWN'S SYNDROME there are two different cell lines, one normal and the other with an additional chromosome 21 (trisomy 21). The effect of mosaicism varies with the proportion of cells containing abnormal chromosomes. Compare CHIMERA.

Mosaicism

A genetic condition resulting from a mutation, crossing over, or nondisjunction of chromosomes during cell division, causing a variation in the number of chromosomes in the cells.
Mentioned in: Patau Syndrome

mosaicism

the presence in an individual animal of cells derived from the same zygote, but differing in chromosomal constitution.
References in periodicals archive ?
Detection of aneuploidy and chromosomal mosaicism in human embryos during preimplantation sex determination by fluorescent in situ hybridisation (FISH).
There could be some reasons for lack of demonstration of chromosomal mosaicism in all individuals with HI[10]: (1) most cytogenetic studies have been directed so far at peripheral lymphocytes or at cultured fibroblasts obtained from skin biopsies rather than at cultured keratinocytes or melanocytes (lines of Blaschko are epidermal not dermal), and (2) some genetic mosaicisms are too subtle to be detected by current techniques.
The downside of using FISH is that it is applied at the blastomere stage, which does not represent the rest of the embryo and is susceptible to chromosomal mosaicism in embryos during cell division, which can lead to the transfer of abnormal embryos.
The percentage of chromosomal mosaicism was then calculated according to the following equation: ([NCR.
Screening of human placentas for chromosomal mosaicism using comparative genomic hybridization.