CHRD

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CHRD

A gene on chromosome 3q27 that encodes chordin, a secreted protein that dorsalises early vertebrate embryonic tissues by binding to ventralising TGF-beta-like bone morphogenetic proteins (BMPs), sequestering them in latent complexes, and may be involved in organogenesis.
References in periodicals archive ?
Vertebrates develop a corresponding dorsal-ventral gradient with bone morphogentic protein (BMP, homologous to DPP) and chordin (homologous to SOG).
Differential regulation of the bone morphogenic protein antagonist chordin in human normal and osteoarthritic chondrocytes.
More recent studies have shown that genes such as noggin, follistatin, chordin, cerberus, and xnr3 may be involved in neural induction.
2, 1994 Cell, De Robertis and his colleagues reported isolating a gene called chordin.
But De Robertis' group forced other regions to make the protein by injecting into embryos chordin messenger RNA (mRNA) a DNA-derived molecule that contains the instructions for building the gene's protein.
We don't believe there's any difference in how sog functions in flies and chordin functions in frogs," says Bier.
The fly protein encoded by sog and the frog protein encoded by chordin can be substituted for one another in developing frog and fruit fly embryos, reports a collaboration of groups headed by Ferguson, De Robertis, and F.
The investigators injected sog mRNA into frog embryos and observed that it promoted the maturation of dorsal structures, just as chordin normally would.