The company has established a commercial beachhead in Europe for its technology, which allows for the implantation of artificial chordae tendinae
, a technique for the repair of mitral valve prolapse, via a transapical, off-pump procedure," Chung said.
In a study comparing cardiac adverse effects of pimobendan with benazepril, (21) dogs with mitral valve regurgitation had increases in systolic function but also developed worsening mitral valve disease, specifically mitral valve lesions (acute hemorrhages, endocardial papilloform hyperplasia on the dorsal surfaces of the leaflets, and infiltration of chordae tendinae
by glycosaminoglycans) not seen in the benazepril group.
The thickening of the valve leaflets and fibrosis of the chordae tendinae
convert the valve into a rigid cylinder of dense scar tissue, immobilizing the posterior wall of the left ventricle with atrophy of this immobilized posterior papillary muscle (10).
The true chordae tendinae
are fibrous strings that usually originate from the apical portion of the anterior and posterior left ventricular papillary muscles or directly from the ventricular wall, inserting into the valve leaflet.
TACT Trial results, recently reported at TCT and EACTS, show good safety and efficacy for NeoChord's sternal-sparing, beating-heart procedure to implant artificial chordae tendinae
There have been some developments in the techniques of mitral valve repair with a move towards more use of artificial chordae tendinae
and preservation of leaflet tissue rather than resection and increasing use of less invasive techniques (84, 89).
The left atrioventricular (AV) valve is thin, bicuspid, and membranous, whereas the right AV valve is a simple muscular flap devoid of chordae tendinae
NeoChord's technology allows the implantation of artificial chordae tendinae
, a proven technique for the repair of mitral valve prolapse via a transapical, off-pump procedure," said Dr.
The mitral valve (MV) is a complex anatomical structure consisting of two leaflets, an annulus, chordae tendinae
, and papillary muscles.
Transthoracic and transesophageal echocardiography showed an elongated anterior mitral chordae tendinae
swinging in the left ventricle and it was also protruding into the left ventricular outflow tract (LVOT) during systole (Fig.
Acute and chronic results using NeoChord's sternal-sparing, beating-heart, mitral valve repair system to implant artificial chordae tendinae
It also poses diagnostic difficulties during echocardiography where it could be confused with right atrial thrombi, tumors, right heart vegetations, flail tricuspid leaflet, or a ruptured chordae tendinae