CHST3

(redirected from Chondroitin 6-sulfotransferase)

CHST3

A gene on chromosome 10q22.1 that encodes a sulfotransferase which transfers sulfate to chondroitin, yielding chondroitin sulfate, a predominant proteoglycan of cartilage, cell surfaces and extracellular matrices. CHST3 can also transfer sulfate to keratan, another glycosaminoglycan, and to sialyl N-acetyllactosamine oligosaccharides. It may play a role in maintaining naive T cells in the spleen.
 
Molecular pathology
Defects in CHST3 are a cause of spondyloepiphyseal dysplasia with congenital joint dislocations (SEDC-JD).
References in periodicals archive ?
The biosynthesis of GAG structures differs from the "small O-linked glycans" in 2 significant ways: (a) the transferases required are all specific and not involved in other glycoconjugate classes, with the exception of chondroitin 6-sulfotransferase, keratan sulfate Gal-6-sulfotransferase, and the GlcNAc 6-O-sulfotransferase that also sulfates N-acetyllactosamine extensions (60); and (b) the mechanism of GAG chain elongation is different.
The CHST3 gene encodes chondroitin 6-sulfotransferase 1 (EC 2.
Diagnosis: Chondroitin 6-sulfotransferase 1 activity can be measured in human fibroblasts (111).

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